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De Freitas JM, et al.  (2004) Exploratory and confirmatory gene expression profiling of mac1Delta. J Biol Chem 279(6):4450-8

Abstract: Exploratory outlier identification methods and confirmatory gene expression studies showed induction of the iron regulon in Saccharomyces cerevisiae lacking Mac1p, a copper-responsive transcription factor. The Aft1p/Aft2p binding motif was the most discriminating motif between up- and down-regulated genes, and we identified new genes potentially regulated by Aft1p/Aft2p. In addition, multiple genes encoding proteins containing Fe-S clusters were down-regulated suggesting metabolic reorganization to conserve iron in mac1Delta. Null mutants of each of the differentially expressed genes were characterized for copper- or iron-related phenotypes. New or additional support for a role in copper and iron homeostasis is provided in this study for the gene products of AKR1, MRS4, PCA1, SSU1, TIS11, YBR047W, YHL035C, YHR045W, YLR047C, YLR126C, and YTP1.

Status: Published Type: Journal Article PubMed ID: 14534306

Topics addressed in this paper

Number of different genes curated to this paper: 27

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ACO1 AFT1 AFT2 AKR1 CCC2 CCP1 DIN7 FET3 FIT3 FMP23
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Topics Genes linked to topics (#11 - 20 )
FRE8 HAP4 HMX1 IRC7 LEU1 MAC1 MRS4 NCP1 PCA1 SSU1
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Topics Genes linked to topics (#21 - 27 )
TIS11 VMR1 YER156C YHR045W YLR126C YRO2 YTP1
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