Kushner PJ, et al. (1979) Control of yeast cell types by mobile genes: a test. Proc Natl Acad Sci U S A 76(10):5264-8
Abstract: The yeast Saccharomyces cerevisiae changes cell types by switching the alleles of the mating type locus (MAT) from a to alpha and vice versa. In the cassette model, these switches, --e.g, from a to alpha--occur when a replica of silent alpha information (an alpha "cassette") replaces the resident a cassette at the mating type locus and is thereby expressed. We have identified a mutation in the locus postulated to be the silent alpha information (HMLalpha) and find that a mutation is introduced into the mating type locus as a result of interconversion: HMLalpha(-) MATalpha cells switch to MATa and then to MATalpha(-). The MATalpha(-) mutation leads to defective mating and behaves like some previously identified MATalpha(-) mutations. These observations satisfy the prediction of the cassette and controlling element models that genetic information is transmitted from HMLalpha to the mating type locus.
|Status: Published||Type: Journal Article | Research Support, U.S. Gov't, P.H.S.||PubMed ID: 14627013|
Topics addressed in this paper
Number of different genes curated to this paper: 7
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