SGD Paper 
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Wolf DA and Geyer R (2003) Dynamic release of Cdc34 from SCF. the hand that rocks the cradle. Cell 114(5):532-3
Abstract: Polyubiquitylation is a complex but poorly understood biochemical reaction catalyzed by E3 ubiquitin ligases. In this issue of Cell, Deffenbaugh et al. provide experimental support for a model in which the dynamic release of the ubiquitin-charged E2 Cdc34 from its primary binding site within the rigid cradle-like SCF E3 complex allows for unexpected spatial flexibility to assemble a polyubiquitin chain.
| Status: Published | Type: Comment | Journal Article | PubMed ID: 13678576 |
Topics addressed in this paper
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| Topics | Genes linked to topics |
|---|---|
| CDC34 | |
| Reviews |  |
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