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Bellaoui M, et al.  (2003) Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J 22(16):4304-13

Abstract: Genome-wide synthetic genetic interaction screens with mutants in the mus81 and mms4 replication fork-processing genes identified a novel replication factor C (RFC) homolog, Elg1, which forms an alternative RFC complex with Rfc2-5. This complex is distinct from the DNA replication RFC, the DNA damage checkpoint RFC and the sister chromatid cohesion RFC. As expected from its genetic interactions, elg1 mutants are sensitive to DNA damage. Elg1 is redundant with Rad24 in the DNA damage response and contributes to activation of the checkpoint kinase Rad53. We find that elg1 mutants display DNA replication defects and genome instability, including increased recombination and mutation frequencies, and minichromosome maintenance defects. Mutants in elg1 show genetic interactions with pathways required for processing of stalled replication forks, and are defective in recovery from DNA damage during S phase. We propose that Elg1-RFC functions both in normal DNA replication and in the DNA damage response.

Status: Published Type: Journal Article PubMed ID: 12912927

Topics addressed in this paper

Number of different genes curated to this paper: 40

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
BIM1 BRE1 BRE5 CHL1 CTF18 CTF4 ELG1 KAR3 MID1 MMS4
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Function/Process blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Large-scale genetic interaction yg ball
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Omics yg ball
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Topics Genes linked to topics (#11 - 20 )
MRC1 MRE11 MUS81 PBY1 POL32 RAD24 RAD27 RAD50 RAD51 RAD52
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Topics Genes linked to topics (#21 - 30 )
RAD53 RAD54 RAD55 RAD57 RFC2 RFC3 RFC4 RFC5 RTT109 SGS1
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Genetic Interactions blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball
Regulation of blue ball
Strains/Constructs blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
SLX5 SLX8 SRS2 SWR1 TOF1 TOP3 XRS2 YBR099C YLR235C YOR1
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