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Cliften P, et al.  (2003) Finding functional features in Saccharomyces genomes by phylogenetic footprinting. Science 301(5629):71-6

Abstract: The sifting and winnowing of DNA sequence that occur during evolution cause nonfunctional sequences to diverge, leaving phylogenetic footprints of functional sequence elements in comparisons of genome sequences. We searched for such footprints among the genome sequences of six Saccharomyces species and identified potentially functional sequences. Comparison of these sequences allowed us to revise the catalog of yeast genes and identify sequence motifs that may be targets of transcriptional regulatory proteins. Some of these conserved sequence motifs reside upstream of genes with similar functional annotations or similar expression patterns or those bound by the same transcription factor and are thus good candidates for functional regulatory sequences.

Status: Published Type: Journal Article PubMed ID: 12775844

Topics addressed in this paper

Number of different genes curated to this paper: 34

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
COX26 ECM9 MCM21 NBL1 OSW2 PBA1 PCC1 RPL20A RRT8 SEA4
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Topics Genes linked to topics (#11 - 20 )
SPO22 SUS1 SWH1 WIP1 YAR044W YBL103C-A YBR056C-B YBR201C-A YCL002C YCL048W-A
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Topics Genes linked to topics (#21 - 30 )
YDL007C-A YDR461C-A YGL194C-A YIL102C-A YIL156W-B YKL023C-A YKL065W-A YLR146W-A YPL052W-A YPL109C
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Topics Genes linked to topics (#31 - 34 )
YPR098C YPR145C-A YPR170W-B YSF3
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