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Rutherford JC, et al.  (2003) Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem 278(30):27636-43

Abstract: The transcription factors Aft1p and Aft2p from Saccharomyces cerevisiae regulate the expression of genes that are involved in iron homeostasis. In vitro studies have shown that both transcription factors bind to an iron-responsive element (FeRE) that is present in the upstream region of genes in the iron regulon. We have used DNA microarrays to distinguish the genes that are activated by Aft1p and Aft2p and to establish for the first time that each factor gives rise to a unique transcriptional profile due to the differential expression of individual iron-regulated genes. We also show that both Aft1p and Aft2p mediate the in vivo expression of FET3 and FIT3 through a consensus FeRE. In addition, both proteins regulate MRS4 via a variant FeRE with Aft2p being the stronger activator from this particular element. Like other paralogous pairs of transcription factors within S. cerevisiae, Aft1p and Aft2p are able to interact with the same promoter elements while maintaining specificity of gene activation.

Status: Published Type: Journal Article PubMed ID: 12756250

Topics addressed in this paper

Number of different genes curated to this paper: 40

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
AFT1 AFT2 AKR1 APE1 ARA2 ARN1 ATG34 ATX1 BIO5 BNA2
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DNA/RNA Sequence Features blue ball blue ball
Function/Process blue ball blue ball
Genomic expression study yg ball
Omics yg ball
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Protein-Nucleic Acid Interactions blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
CAD1 COT1 ECL1 ECM4 ENB1 FET3 FIT1 FIT2 FIT3 FRE1
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DNA/RNA Sequence Features blue ball blue ball
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Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
FRE2 FRE3 FRE5 FRE6 FTR1 HSP26 ISU1 MRS4 OYE3 SIT1
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DNA/RNA Sequence Features blue ball
Primary Literature blue ball
Regulation of blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
SMF3 TAF1 TIS11 VMR1 YBR012C YDR271C YKR104W YMR034C YOR225W YOR387C
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DNA/RNA Sequence Features blue ball
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