Dheur S, et al. (2003) Pti1p and Ref2p found in association with the mRNA 3' end formation complex direct snoRNA maturation. EMBO J 22(11):2831-40
Abstract: Eukaryotic RNA polymerase II transcribes precursors of mRNAs and of non-protein-coding RNAs such as snRNAs and snoRNAs. These RNAs have to be processed at their 3' ends to be functional. mRNAs are matured by cleavage and polyadenylation that require a well-characterized protein complex. Small RNAs are also subject to 3' end cleavage but are not polyadenylated. Here we show that two newly identified proteins, Pti1p and Ref2p, although they were found associated with the pre-mRNA 3' end processing complex, are essential for yeast snoRNA 3' end maturation. We also provide evidence that Pti1p probably acts by uncoupling cleavage and polyadenylation, and functions in coordination with the Nrd1p-dependent pathway for 3' end formation of non-polyadenylated transcripts.
|Status: Published||Type: Journal Article | Research Support, U.S. Gov't, P.H.S.||PubMed ID: 12773397|
Topics addressed in this paper
Number of different genes curated to this paper: 13
- To go to the Locus page for a gene, click on the gene name.
|Topics||Genes (#1 - 10 )|
|RNA Levels and Processing|