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Ganem C, et al.  (2003) Ssu72 is a phosphatase essential for transcription termination of snoRNAs and specific mRNAs in yeast. EMBO J 22(7):1588-98

Abstract: Ssu72 is an essential yeast protein that is involved in transcription. It physically interacts with transcription initiation and termination complexes. In this report, we provide evidence that Ssu72 is a phosphatase that physically interacts with the CTD kinase Kin28 and functionally interacts with the CTD phosphatase Fcp1. A genome-wide expression analysis of mutant ssu72-ts69 during growth in complete medium revealed a number of defects, including the accumulation of a limited number of mRNAs and the read-through transcription of small nucleolar RNAs and of some mRNAs. We hypothesize that Ssu72 plays a key role in the transcription termination of certain transcripts, possibly by promoting RNA polymerase pausing and release. The possibility that the CTD of the largest subunit of RNA polymerase II is a substrate of Ssu72 is discussed.

Status: Published Type: Journal Article PubMed ID: 12660165

Topics addressed in this paper

Number of different genes curated to this paper: 27

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
FCP1 FLX1 KIN28 KTR2 LIN1 NVJ2 SEN2 SMC5 SNR10 SNR13
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball
Genetic Interactions blue ball blue ball
Genomic expression study yg ball
Mutants/Phenotypes blue ball blue ball
Omics yg ball
Primary Literature blue ball blue ball
Protein-protein Interactions blue ball
RNA Levels and Processing blue ball blue ball
Strains/Constructs blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
SNR33 SNR41 SNR42 SNR47 SNR50 SNR51 SNR68 SNR70 SNR71 SNR79
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 27 )
SNR8 SSU72 TRS31 YCR015C YDR042C YGL088W YTM1
Additional Literature blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Fungal Related Genes/Proteins blue ball
Genetic Interactions blue ball
Mutants/Phenotypes blue ball
Non-Fungal Related Genes/Proteins blue ball
Primary Literature blue ball blue ball
Protein-protein Interactions blue ball
Protein/Nucleic Acid Structure blue ball
RNA Levels and Processing blue ball
Strains/Constructs blue ball
Substrates/Ligands/Cofactors blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball

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