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Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91

Abstract: Determining the effect of gene deletion is a fundamental approach to understanding gene function. Conventional genetic screens exhibit biases, and genes contributing to a phenotype are often missed. We systematically constructed a nearly complete collection of gene-deletion mutants (96% of annotated open reading frames, or ORFs) of the yeast Saccharomyces cerevisiae. DNA sequences dubbed 'molecular bar codes' uniquely identify each strain, enabling their growth to be analysed in parallel and the fitness contribution of each gene to be quantitatively assessed by hybridization to high-density oligonucleotide arrays. We show that previously known and new genes are necessary for optimal growth under six well-studied conditions: high salt, sorbitol, galactose, pH 8, minimal medium and nystatin treatment. Less than 7% of genes that exhibit a significant increase in messenger RNA expression are also required for optimal growth in four of the tested conditions. Our results validate the yeast gene-deletion collection as a valuable resource for functional genomics.AD - Stanford Genome Technology Center, Stanford University,Palo Alto, California 94304, USA.FAU - Giaever, Gur.

Status: Published Type: Journal Article PubMed ID: 12140549

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ADD37 AIM10 AIM11 AIM21 AIM22 AIM25 AIM26 AIM29 AIM3 AIM32
Large-scale phenotype analysis yg ball
Omics yg ball
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AIM34 AIM39 AIM4 AIM41 AIM6 AIM7 ARA2 ART10 ASA1 ATG36
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ATP25 BER1 BLS1 BXI1 CAB2 CAB4 CAB5 CMS1 CSI2 CTR86
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Topics Genes linked to topics (#31 - 40 )
DAS1 DPH6 EAR1 EIS1 ENV10 EOS1 ESL2 FDC1 FRA1 FUB1
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Topics Genes linked to topics (#41 - 50 )
GEP7 GPN3 GRX8 HER2 INN1 IRC20 JIP5 KEG1 KEI1 LAA1
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Topics Genes linked to topics (#51 - 60 )
LAP2 LDH1 LTO1 MNL2 MSA2 MTC1 MVB12 NSE3 OCA2 OSW5
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Topics Genes linked to topics (#61 - 70 )
PAR32 PAU11 PAU13 PAU17 PAU8 PER33 PGA1 PGM3 RMR1 ROY1
Mutants/Phenotypes blue ball
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RRG7 RRT12 RTP1 RTR2 SAW1 SEG1 SFM1 SRV2 TAM41 TDA1
Additional Literature blue ball
Mutants/Phenotypes blue ball
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Topics Genes linked to topics (#81 - 90 )
TDA3 TDA8 TDA9 TMN3 TRI1 TRM44 TRM732 TSR4 USB1 VBA4
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Topics Genes linked to topics (#91 - 100 )
YAE1 YAL042C-A YBL029W YBL065W YBL081W YBL096C YBR063C YBR174C YBR184W YBR219C
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#101 - 110 )
YBR220C YBR225W YBR259W YCL001W-A YCL002C YCR015C YCR023C YDL057W YDL073W YDL114W
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#111 - 120 )
YDL144C YDL177C YDL183C YDR124W YDR161W YDR336W YDR387C YDR476C YEL1 YER034W
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Topics Genes linked to topics (#121 - 130 )
YER134C YFL040W YFL042C YFL051C YFR039C YGL036W YGL081W YGL140C YGL176C YGL230C
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#131 - 140 )
YGL242C YGL262W YGR051C YGR079W YGR168C YGR273C YHI9 YHL026C YHL042W YHL045W
Mutants/Phenotypes blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball

Topics Genes linked to topics (#141 - 150 )
YHR022C YHR035W YHR210C YIL024C YIL060W YIL161W YIL166C YIL169C YIR007W YIR014W
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#151 - 160 )
YIR016W YIR042C YJL043W YJL049W YJL070C YJL118W YJL132W YJL147C YJL160C YJL218W
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#161 - 170 )
YJR012C YJR015W YJR030C YJR037W YJR141W YKL100C YLL007C YLL032C YLL056C YLL058W
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#171 - 180 )
YLR001C YLR012C YLR036C YLR040C YLR042C YLR050C YLR063W YLR072W YLR108C YLR125W
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#181 - 190 )
YLR126C YLR149C YLR152C YLR179C YLR211C YLR224W YLR225C YLR253W YLR271W YLR281C
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#191 - 200 )
YLR283W YLR287C YLR290C YLR297W YLR345W YLR346C YLR365W YLR407W YLR413W YLR415C
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#201 - 210 )
YLR422W YLR446W YLR455W YML037C YML053C YML079W YML082W YML083C YML096W YML108W
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#211 - 220 )
YML119W YMR010W YMR018W YMR027W YMR034C YMR074C YMR090W YMR099C YMR102C YMR111C
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#221 - 230 )
YMR114C YMR124W YMR130W YMR134W YMR144W YMR158C-A YMR160W YMR166C YMR178W YMR181C
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#231 - 240 )
YMR187C YMR196W YMR206W YMR209C YMR226C YMR252C YMR253C YMR262W YMR295C YMR310C
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#241 - 250 )
YMR315W YMR317W YNL010W YNL011C YNL022C YNL024C YNL034W YNL035C YNL040W YNL046W
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#251 - 260 )
YNL050C YNL058C YNL092W YNL095C YNL108C YNL115C YNL122C YNL144C YNL146W YNL165W
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#261 - 270 )
YNL181W YNL211C YNR021W YNR065C YOL114C YOL159C YOR050C YOR114W YOR131C YOR268C
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#271 - 280 )
YOR283W YOR292C YOR376W YPL034W YPL039W YPL062W YPL067C YPL107W YPL216W YPL229W
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#281 - 282 )
YPL247C YPR071W
Primary Literature blue ball blue ball

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