Neupert W and Brunner M (2002) The protein import motor of mitochondria. Nat Rev Mol Cell Biol 3(8):555-65
Abstract: Proteins that are destined for the matrix of mitochondria are transported into this organelle by two translocases: the TOM complex, which transports proteins across the outer mitochondrial membrane; and the TIM23 complex, which gets them through the inner mitochondrial membrane. Two models have been proposed to explain how this protein-import machinery works -- a targeted Brownian ratchet, in which random motion is translated into vectorial motion, or a 'power stroke', which is exerted by a component of the import machinery. Here, we review the data for and against each model.
|Status: Published||Type: Journal Article | Review | Review, Tutorial||PubMed ID: 12154367|
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