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Stevens SW, et al.  (2002) Composition and functional characterization of the yeast spliceosomal penta-snRNP. Mol Cell 9(1):31-44

Abstract: Pre-mRNA introns are spliced in a macromolecular machine, the spliceosome. For each round of splicing, the spliceosome assembles de novo in a series of ATP-dependent steps involving numerous changes in RNA-RNA and RNA-protein interactions. As currently understood, spliceosome assembly proceeds by addition of discrete U1, U2, and U4/U6*U5 snRNPs to a pre-mRNA substrate to form functional splicing complexes. We characterized a 45S yeast penta-snRNP which contains all five spliceosomal snRNAs and over 60 pre-mRNA splicing factors. The particle is functional in extracts and, when supplied with soluble factors, is capable of splicing pre-mRNA. We propose that the spliceosomal snRNPs associate prior to binding of a pre-mRNA substrate rather than with pre-mRNA via stepwise addition of discrete snRNPs.

Status: Published Type: Journal Article PubMed ID: 11804584

Topics addressed in this paper

Number of different genes curated to this paper: 90

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Topics Genes linked to topics (#1 - 10 )
ASC1 BNA7 BRR2 BUD31 CEF1 CLF1 CUS1 CUS2 DED1 DHH1
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DIB1 ECM2 GPM1 HSH155 HSH49 IMD1 IMD2 IMD3 IMD4 IST3
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Topics Genes linked to topics (#21 - 30 )
ISY1 LEA1 LSM1 LSM2 LSM3 LSM4 LSM6 LSM7 LSM8 LUC7
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Topics Genes linked to topics (#31 - 40 )
MBP1 MSL1 MUD1 NAM8 NOP1 NTC20 PAT1 PML1 PRP11 PRP19
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Topics Genes linked to topics (#41 - 50 )
PRP21 PRP3 PRP31 PRP38 PRP39 PRP4 PRP40 PRP42 PRP45 PRP46
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Topics Genes linked to topics (#51 - 60 )
PRP6 PRP8 PRP9 RPS0A RPS0B RPS5 RSE1 RSP1 SAD1 SIS1
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Topics Genes linked to topics (#61 - 70 )
SMB1 SMD1 SMD2 SMD3 SME1 SMX2 SMX3 SNP1 SNT309 SNU114
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Topics Genes linked to topics (#71 - 80 )
SNU13 SNU23 SNU56 SNU66 SNU71 SPP381 SSA1 SSA2 SSA3 SSA4
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Topics Genes linked to topics (#81 - 90 )
SSB1 SSB2 SWI4 SWI6 SYF1 SYF2 TDH1 TEF1 XRN1 YHC1
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