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Lehmann A, et al.  (2002) 20 S proteasomes are imported as precursor complexes into the nucleus of yeast. J Mol Biol 317(3):401-13

Abstract: The mechanism by which yeast 20 S proteasomes are imported into the nucleus is still unresolved. Here, we provide the first evidence that 20S proteasomes are imported as precursor complexes into the nucleus. By using the srp1-49 mutant which is deficient in nuclear import of cargos with classical nuclear localization sequences (cNLS), we show that proteasome precursor complexes associate with importin/karyopherin alphabeta, the cNLS receptor, and that they accumulate inside the cytoplasm. Reconstitution assays revealed that only precursor complexes are targeted to the nuclear envelope (NE) by karyopherin alphabeta. In support, the green fluorescent protein (GFP)-labelled maturation factor Ump1, marking precursor complexes, mainly localizes to the nucleus and around the NE. Our data suggest that nuclear 20 S proteasomes are finally matured inside the nucleus.CI - Copyright 2002 Elsevier Science Ltd.

Status: Published Type: Journal Article PubMed ID: 11922673

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
PRE1 PRE10 PRE2 PRE3 PRE4 PRE5 PRE6 PRE7 PRE8 PRE9
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 16 )
PUP1 PUP2 PUP3 SCL1 SRP1 UMP1
Additional Literature blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball
Primary Literature blue ball
Protein Processing/Modification/Regulation blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball
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