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Maiorano D and Mechali M  (2002) Many roads lead to the origin. Nat Cell Biol 4(3):E58-9

Abstract: The assembly of the DNA helicase at replication origins is crucial in initiating DNA synthesis. This process requires the conserved protein Cdt1. Here, a new study identifies a functional homologue of Cdt1 in Saccharomyces cerevisiae. The regulation of its activity reveals an alternative way to assemble prereplicative complexes (pre-RCs) and regulate origin function.

Status: Published Type: Journal Article PubMed ID: 11875449

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