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Fleming JA, et al.  (2002) Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341. Proc Natl Acad Sci U S A 99(3):1461-6

Abstract: Although the biochemical targets of most drugs are known, the biological consequences of their actions are typically less well understood. In this study, we have used two whole-genome technologies in Saccharomyces cerevisiae to determine the cellular impact of the proteasome inhibitor PS-341. By combining population genomics, the screening of a comprehensive panel of bar-coded mutant strains, and transcript profiling, we have identified the genes and pathways most affected by proteasome inhibition. Many of these function in regulated protein degradation or a subset of mitotic activities. In addition, we identified Rpn4p as the transcription factor most responsible for the cell's ability to compensate for proteasome inhibition. Used together, these complementary technologies provide a general and powerful means to elucidate the cellular ramifications of drug treatment.

Status: Published Type: Journal Article PubMed ID: 11830665

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APN1 ATG17 BEM4 BIK1 CCR4 CDC26 CHL1 CHL4 CLB2 CLB5
Genomic expression study yg ball
Large-scale phenotype analysis yg ball
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Topics Genes linked to topics (#11 - 20 )
CSM3 CTF19 CTF8 DCC1 DOA4 ERG2 ERG3 ERG4 FYV7 GET2
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
HNT3 HTA1 IDP1 IML3 IRC15 LTE1 MCM21 NEM1 NUP2 PDR5
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Topics Genes linked to topics (#31 - 40 )
PFD1 PRE9 PRO1 RAD50 RAD51 RIC1 RPN10 RPN4 RTT107 SAP30
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Topics Genes linked to topics (#41 - 50 )
SCP160 SHE1 SIC1 SIN3 SNF2 SNQ2 SPO7 SRC1 SWI3 SWM1
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TOF1 TUB3 UBX2 VAC14 VAM3 VIK1 VPS61 WHI3 YAP1 YME1
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Topics Genes linked to topics (#61 )
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