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Wyrick JJ, et al.  (2001) Genome-wide distribution of ORC and MCM proteins in S. cerevisiae: high-resolution mapping of replication origins. Science 294(5550):2357-60

Abstract: DNA replication origins are fundamental to chromosome organization and duplication, but understanding of these elements is limited because only a small fraction of these sites have been identified in eukaryotic genomes. Origin Recognition Complex (ORC) and minichromosome maintenance (MCM) proteins form prereplicative complexes at origins of replication. Using these proteins as molecular landmarks for origins, we identified ORC- and MCM-bound sites throughout the yeast genome. Four hundred twenty-nine sites in the yeast genome were predicted to contain replication origins, and approximately 80% of the loci identified on chromosome X demonstrated origin function. A substantial fraction of the predicted origins are associated with repetitive DNA sequences, including subtelomeric elements (X and Y') and transposable element-associated sequences (long terminal repeats). These findings identify the global set of yeast replication origins and open avenues of investigation into the role(s) ORC and MCM proteins play in chromosomal architecture and dynamics.

Status: Published Type: Journal Article PubMed ID: 11743203

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Topics Genes linked to topics (#31 - 40 )
ARS1202 ARS1207 ARS1208 ARS1214 ARS1219 ARS1221 ARS1228 ARS1230 ARS1304 ARS1317
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ARS1319 ARS1321 ARS1322 ARS1331 ARS1333 ARS1335 ARS1409 ARS1410 ARS1416 ARS1423
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Topics Genes linked to topics (#51 - 60 )
ARS1425 ARS1502 ARS1512 ARS1516 ARS1518 ARS1603 ARS1608 ARS1611 ARS1612 ARS1617
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ARS1620 ARS1629 ARS1632 ARS2 ARS209 ARS404 ARS411 ARS412 ARS415 ARS420
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Topics Genes linked to topics (#71 - 80 )
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Topics Genes linked to topics (#81 - 90 )
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Topics Genes linked to topics (#91 - 97 )
ARS902 ARS904 ARS910 ARS915 ARS918 ARS921 MCM3
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