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Colman-Lerner A, et al.  (2001) Yeast Cbk1 and Mob2 activate daughter-specific genetic programs to induce asymmetric cell fates. Cell 107(6):739-50

Abstract: In Saccharomyces cerevisiae, mothers and daughters have distinct fates. We show that Cbk1 kinase and its interacting protein Mob2 regulate this asymmetry by inducing daughter-specific genetic programs. Daughter-specific expression is due to Cbk1/Mob2-dependent activation and localization of the Ace2 transcription factor to the daughter nucleus. Ectopic localization of active Ace2 to mother nuclei is sufficient to activate daughter-specific genes in mothers. Eight genes are daughter-specific under the tested conditions, while two are daughter-specific only in saturated cultures. Some daughter-specific gene products contribute to cell separation by degrading the cell wall. These experiments define programs of gene expression specific to daughters and describe how those programs are controlled.

Status: Published Type: Journal Article PubMed ID: 11747810

Topics addressed in this paper

Number of different genes curated to this paper: 12

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Topics Genes linked to topics (#1 - 10 )
ACE2 AMN1 ASH1 CBK1 CTS1 DSE1 DSE2 DSE3 DSE4 MOB2
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Topics Genes linked to topics (#11 - 12 )
PRY3 SCW11
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