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Asturias FJ, et al.  (1999) Conserved structures of mediator and RNA polymerase II holoenzyme. Science 283(5404):985-7

Abstract: Single particles of the mediator of transcriptional regulation (Mediator) and of RNA polymerase II holoenzyme were revealed by electron microscopy and image processing. Mediator alone appeared compact, but at high pH or in the presence of RNA polymerase II it displayed an extended conformation. Holoenzyme contained Mediator in a fully extended state, partially enveloping the globular polymerase, with points of apparent contact in the vicinity of the polymerase carboxyl-terminal domain and the DNA-binding channel. A similarity in appearance and conformational behavior of yeast and murine complexes indicates a conservation of Mediator structure among eukaryotes.

Status: Published Type: Journal Article PubMed ID: 9974391

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GAL11 MED1 MED2 MED4 MED6 MED7 MED8 PGD1 RGR1 ROX3
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Topics Genes linked to topics (#11 - 17 )
RPO21 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball
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