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Behr JB, et al.  (2001) Inhibition of chitin synthetase from Saccharomyces cerevisiae by a new UDP-GlcNAc analogue. J Enzyme Inhib 16(2):107-12

Abstract: The synthesis and biological evaluation of a new UDP-GlcNAc competitor (I), designed to mimic the transition state of the sugar donor in the enzymatic reaction catalysed by chitin synthetase, is described. Compound (I) was found to competitively inhibit chitin synthetase from Saccharomyces cerevisiae with respect to UDP-GlcNAc, but displayed minimal antifungal activity.

Status: Published Type: Journal Article PubMed ID: 11342279

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