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Dickson RC and Lester RL  (1999) Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 1438(3):305-21

Abstract: Our knowledge of sphingolipid metabolism and function in Saccharomyces cerevisiae is growing rapidly. Here we discuss the current status of sphingolipid metabolism including recent evidence suggesting that exogenous sphingoid long-chain bases must first be phosphorylated and then dephosphorylated before incorporation into ceramide. Phenotypes of strains defective in sphingolipid metabolism are discussed because they provide hints about the undiscovered functions of sphingolipids and are one of the major reasons for studying this model eukaryote. The long-chain base phosphates, dihydrosphingosine-1-phosphate and phytosphingosine-1-phosphate, have been hypothesized to play roles in heat stress resistance, perhaps acting as signaling molecules. We evaluate the data supporting this hypothesis and suggest future experiments needed to verify it. Finally, we discuss recent clues that may help to reveal how sphingolipid synthesis and total cellular sphingolipid content are regulated.

Status: Published Type: Journal Article | Review | Review, Tutorial PubMed ID: 10366774

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
AUR1 CSG2 DPL1 ERG2 FAS2 FEN1 IPT1 LCB1 LCB2 LCB3
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Fungal Related Genes/Proteins blue ball blue ball
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Non-Fungal Related Genes/Proteins blue ball blue ball
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Protein Sequence Features blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
LCB4 LCB5 MSN2 MSN4 MSS4 RPD3 SCS7 SIN3 SUR1 SUR2
Alias blue ball blue ball
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Cellular Location blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Mutants/Phenotypes blue ball blue ball blue ball blue ball
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Protein Sequence Features blue ball blue ball
Protein-protein Interactions blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball
Reviews blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball
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Topics Genes linked to topics (#21 - 26 )
SUR4 TOR2 TSC10 TSC11 TSC13 YSR3
Alias blue ball blue ball
Cell Cycle Phase Involved blue ball blue ball
Cellular Location blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball
Protein Sequence Features blue ball
Regulatory Role blue ball
Reviews blue ball blue ball blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball
Strains/Constructs blue ball blue ball blue ball blue ball
Substrates/Ligands/Cofactors blue ball

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