Warner JR (1999) The economics of ribosome biosynthesis in yeast. Trends Biochem Sci 24(11):437-40
Abstract: In a rapidly growing yeast cell, 60% of total transcription is devoted to ribosomal RNA, and 50% of RNA polymerase II transcription and 90% of mRNA splicing are devoted to ribosomal proteins (RPs). Coordinate regulation of the approximately 150 rRNA genes and 137 RP genes that make such prodigious use of resources is essential for the economy of the cell. This is entrusted to a number of signal transduction pathways that can abruptly induce or silence the ribosomal genes, leading to major implications for the expression of other genes as well.
Type: Journal Article | Review | Review, Tutorial
PubMed ID: 10542411
Topics addressed in this paper
Number of different genes curated to this paper: 155
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