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Epstein CB, et al.  (2001) Genome-wide responses to mitochondrial dysfunction. Mol Biol Cell 12(2):297-308

Abstract: Mitochondrial dysfunction can lead to diverse cellular and organismal responses. We used DNA microarrays to characterize the transcriptional responses to different mitochondrial perturbations in Saccharomyces cerevisiae. We examined respiratory-deficient petite cells and respiratory-competent wild-type cells treated with the inhibitors of oxidative phosphorylation antimycin, carbonyl cyanide m-chlorophenylhydrazone, or oligomycin. We show that respiratory deficiency, but not inhibition of mitochondrial ATP synthesis per se, induces a suite of genes associated with both peroxisomal activities and metabolite-restoration (anaplerotic) pathways that would mitigate the loss of a complete tricarboxylic acid cycle. The array data suggested, and direct microscopic observation of cells expressing a derivative of green fluorescent protein with a peroxisomal matrix-targeting signal confirmed, that respiratory deficiency dramatically induces peroxisome biogenesis. Transcript profiling of cells harboring null alleles of RTG1, RTG2, or RTG3, genes known to control signaling from mitochondria to the nucleus, suggests that there are multiple pathways of cross-talk between these organelles in yeast.

Status: Published Type: Journal Article PubMed ID: 11179416

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ACO1 ACS1 ADH2 ADY2 AGP1 AGP2 ALD4 ALT1 ATO3 BAT2
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BIO2 CAR1 CDA1 CIT1 CIT2 CIT3 CRC1 CTF19 DIC1 DIP5
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DLD1 ERR2 FRE4 FUI1 FZF1 GAP1 GPD2 HMS1 HXT10 HXT2
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Topics Genes linked to topics (#31 - 40 )
ICL2 IDH2 IRC14 IRC18 IZH4 JEN1 LEE1 LEU1 MCH4 MCH5
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Topics Genes linked to topics (#41 - 50 )
NCE103 NRG1 PDH1 PDR15 PEX11 PHO84 PHO89 PIG2 PRM1 PUT1
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PUT2 PXA1 PYC1 REE1 RGI2 RGS2 RTG1 RTG2 RTG3 SPG5
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Topics Genes linked to topics (#61 - 70 )
SPL2 SPO1 SPS19 SUC2 THI73 TIS11 TNA1 VID24 YAR068W YER158C
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Topics Genes linked to topics (#71 - 77 )
YER187W YGR259C YJL213W YKR075C YLR346C YLR349W YNL203C
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