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Palecek SP, et al.  (2000) Genetic analysis reveals that FLO11 upregulation and cell polarization independently regulate invasive growth in Saccharomyces cerevisiae. Genetics 156(3):1005-23

Abstract: Under inducing conditions, haploid Saccharomyces cerevisiae perform a dimorphic transition from yeast-form growth on the agar surface to invasive growth, where chains of cells dig into the solid growth medium. Previous work on signaling cascades that promote agar invasion has demonstrated upregulation of FLO11, a cell-surface flocculin involved in cell-cell adhesion. We find that increasing FLO11 transcription is sufficient to induce both invasive and filamentous growth. A genetic screen for repressors of FLO11 isolated mutant strains that dig into agar (dia) and identified mutations in 35 different genes: ELM1, HSL1, HSL7, BUD3, BUD4, BUD10, AXL1, SIR2, SIR4, BEM2, PGI1, GND1, YDJ1, ARO7, GRR1, CDC53, HSC82, ZUO1, ADH1, CSE2, GCR1, IRA1, MSN5, SRB8, SSN3, SSN8, BPL1, GTR1, MED1, SKN7, TAF25, DIA1, DIA2, DIA3, and DIA4. Indeed, agar invasion in 20 dia mutants requires upregulation of the endogenous FLO11 promoter. However, 13 mutants promote agar invasion even with FLO11 clamped at a constitutive low-expression level. These FLO11 promoter-independent dia mutants establish distinct invasive growth pathways due to polarized bud site selection and/or cell elongation. Epistasis with the STE MAP kinase cascade and cytokinesis/budding checkpoint shows these pathways are targets of DIA genes that repress agar invasion by FLO11 promoter-dependent and -independent mechanisms, respectively.

Status: Published Type: Journal Article PubMed ID: 11063681

Topics addressed in this paper

Number of different genes curated to this paper: 36

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Topics Genes linked to topics (#1 - 10 )
ADH1 ARO7 AXL1 AXL2 BEM2 BPL1 BUD3 BUD4 CDC53 CSE2
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Topics Genes linked to topics (#11 - 20 )
DIA1 DIA2 DIA3 DIA4 ELM1 FLO11 GCR1 GND1 GRR1 GTR1
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Topics Genes linked to topics (#21 - 30 )
HSC82 HSL1 HSL7 IRA1 MED1 MSN5 PGI1 SIR2 SIR4 SKN7
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Topics Genes linked to topics (#31 - 36 )
SRB8 SSN3 SSN8 TAF10 YDJ1 ZUO1
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