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Cairns BR, et al.  (1999) Two functionally distinct forms of the RSC nucleosome-remodeling complex, containing essential AT hook, BAH, and bromodomains. Mol Cell 4(5):715-23

Abstract: RSC is an essential 15 protein nucleosome-remodeling complex from S. cerevisiae. We have identified two closely related RSC members, Rsc1 and Rsc2. Biochemical analysis revealed Rsc1 and Rsc2 in distinct complexes, defining two forms of RSC. Genetic analysis has shown that Rsc1 and Rsc2 possess shared and unique functions. Rsc1 and Rsc2 each contain two bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook. One of the bromodomains, the BAH domain, and the AT hook are each essential for Rsc1 and Rsc2 functions, although they are not required for assembly into RSC complexes. Therefore, these domains are required for RSC function. Additional genetic analysis provides further evidence that RSC function is related to transcriptional control.

Status: Published Type: Journal Article PubMed ID: 10619019

Topics addressed in this paper

Number of different genes curated to this paper: 14

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Topics Genes linked to topics (#1 - 10 )
ARP7 ARP9 LDB7 NPL6 RSC1 RSC2 RSC3 RSC4 RSC6 RSC8
DNA/RNA Sequence Features blue ball blue ball
Function/Process blue ball blue ball
Genetic Interactions blue ball blue ball
Mutants/Phenotypes blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball

Topics Genes linked to topics (#11 - 14 )
RSC9 SFH1 SNF2 STH1
Genetic Interactions blue ball
Mutants/Phenotypes blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein Sequence Features blue ball
Protein-protein Interactions blue ball blue ball
Strains/Constructs blue ball

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