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Karpichev IV and Small GM  (1998) Global regulatory functions of Oaf1p and Pip2p (Oaf2p), transcription factors that regulate genes encoding peroxisomal proteins in Saccharomyces cerevisiae. Mol Cell Biol 18(11):6560-70

Abstract: Two transcription factors, Oaf1p and Pip2p (Oaf2p), are key components in the pathway by which several Saccharomyces cerevisiae genes encoding peroxisomal proteins are activated in the presence of a fatty acid such as oleate. By searching the S. cerevisiae genomic database for the consensus sequence that acts as a target for these transcription factors, we identified 40 genes that contain a putative Oaf1p-Pip2p binding site in their promoter region. Quantitative Northern analysis confirmed that the expression of 22 of the genes identified is induced by oleate and that either one or both of these transcription factors are required for the activation. In addition to known peroxisomal proteins, the regulated genes encode novel peroxisomal proteins, a mitochondrial protein, and proteins of unknown location and function. We demonstrate that Oaf1p regulates certain genes in the absence of Pip2p and that both of these transcription factors play a role in maintaining the glucose-repressed state of one gene. Furthermore, we provide evidence that the defined consensus binding site is not required for the regulation of certain oleate-responsive genes.

Status: Published Type: Journal Article PubMed ID: 9774671

Topics addressed in this paper

Number of different genes curated to this paper: 42

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Topics Genes linked to topics (#1 - 10 )
ATF1 CAT2 CIN1 CIT1 CIT2 CRC1 CTA1 CUP2 DCI1 DUS3
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Topics Genes linked to topics (#11 - 20 )
ECI1 EEB1 FAA2 FOX2 GRX3 HXK1 IDP3 IFA38 IZH2 MDH3
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Topics Genes linked to topics (#21 - 30 )
MIP6 NNK1 OAF1 PEX11 PEX5 PIP2 POT1 POX1 PXA1 PXA2
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Topics Genes linked to topics (#31 - 40 )
QDR1 RIM101 SAM50 SER1 SPC25 SPS19 TES1 TPS2 UGA3 YAT1
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Topics Genes linked to topics (#41 - 42 )
YJL218W YNL035C
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