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Charron MJ, et al.  (1989) Molecular evolution of the telomere-associated MAL loci of Saccharomyces. Genetics 122(2):307-16

Abstract: The MAL gene family of Saccharomyces consists of five multigene complexes (MAL1, MAL2, MAL3, MAL4, and MAL6) each of which encodes maltose permease (GENE 1), maltase (GENE 2) and the trans-acting MAL-activator (GENE 3). Four of these loci have been mapped and each is located at or near the telomere of a different chromosome. We compare the physical structure of the MAL loci and their flanking sequences. The MAL loci were shown to be both structurally and functionally homologous throughout an approximately 9.0-kb region. The orientation of the MAL loci was determined to be: CENTROMERE... GENE 3-GENE 1-GENE 2... TELOMERE. Telomere-adjacent sequences were found flanking GENE 2 of the MAL1, MAL3 and MAL6 loci. No common repeated elements were found on the centromere-proximal side of all the MAL1, loci. These results suggest that, during the evolution of this polygenic family, the MAL loci translocated to different chromosomes viaa mechanism that involved the rearrangement(s) of chromosome termini.

Status: Published Type: Journal Article PubMed ID: 2548922

Topics addressed in this paper

Number of different genes curated to this paper: 20

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Topics Genes linked to topics (#1 - 10 )
MAL1 MAL12 MAL13 MAL2 MAL22 MAL23 MAL3 MAL31 MAL32 MAL33
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Topics Genes linked to topics (#11 - 20 )
MAL34 MAL4 MAL42 MAL43 MAL6 MAL61 MAL62 MAL63 MAL64 SUC3
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DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball
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Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball blue ball blue ball
Mapping blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball

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