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Keener J, et al.  (1998) Reconstitution of yeast RNA polymerase I transcription in vitro from purified components. TATA-binding protein is not required for basal transcription. J Biol Chem 273(50):33795-802

Abstract: Five purified protein components, RNA polymerase I, Rrn3p, core factor, TBP (TATA-binding protein), and upstream activation factor, are sufficient for high level transcription in vitro from the Saccharomyces cerevisiae rDNA promoter. Rrn3p and pol I form a complex in solution that is active in specific initiation. Three protein components, pol I, Rrn3p, and core factor, and promoter sequence to -38, suffice for basal transcription. Unlike pol II and pol III, yeast pol I basal transcription does not require TBP. Instead, TBP, upstream activation factor, and the upstream element of the promoter together stimulate pol I basal transcription to a fully activated level. The role of TBP in pol I transcription is fundamentally different from its role in pol II or pol III transcription.

Status: Published Type: Journal Article PubMed ID: 9837969

Topics addressed in this paper

Number of different genes curated to this paper: 22

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Topics Genes linked to topics (#1 - 10 )
RPA12 RPA135 RPA14 RPA190 RPA34 RPA43 RPA49 RPB10 RPB5 RPB8
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Topics Genes linked to topics (#11 - 20 )
RPC10 RPC19 RPC40 RPO26 RRN10 RRN11 RRN3 RRN5 RRN6 RRN7
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Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 22 )
RRN9 SPT15
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