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Allmang C and Tollervey D  (1998) The role of the 3' external transcribed spacer in yeast pre-rRNA processing. J Mol Biol 278(1):67-78

Abstract: We have undertaken a deletion analysis of the 3' external transcribed spacer (3' ETS) in the pre-rRNA of Saccharomyces cerevisiae. A stem loop structure immediately 3' to the 25 S rRNA region is necessary and sufficient for processing of the 3' ETS. This is believed to be by cotranscriptional cleavage by Rnt1p, the yeast homologue of RNase III. In addition, this stem-loop is required for cleavage of site A3 by RNase MRP and for processing at site B1L, in the 3' region of ITS1. Processing at an upstream site in ITS1, site A2, and at sites in the 5' external transcribed spacer are not affected, even by complete deletion of the 3' ETS. We conclude that processing in the 3' ETS and in ITS1 is coupled. This would constitute a quality control that prevents synthesis of the 5. 8 S rRNA and 5' end maturation of the 25 S rRNA in transcripts which are incomplete due to premature transcription termination. Copyright 1998 Academic Press Limited.

Status: Published Type: Journal Article PubMed ID: 9571034

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
ETS1-1 ETS1-2 ETS2-1 ETS2-2 ITS1-1 ITS1-2 POP1 POP3 POP4 POP5
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball
Strains/Constructs blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
POP6 POP7 POP8 RDN25-1 RDN25-2 RDN37-1 RDN37-2 RDN58-1 RDN58-2 RNT1
DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball
Transcription blue ball blue ball blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#21 - 22 )
RPR2 SNM1
Function/Process blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball
Primary Literature blue ball blue ball
Protein-Nucleic Acid Interactions blue ball blue ball

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