Colomina N, et al. (1999) G1 cyclins block the Ime1 pathway to make mitosis and meiosis incompatible in budding yeast. EMBO J 18(2):320-9
Abstract: Diploid yeast cells switch from mitosis to meiosis when starved of essential nutrients. While G1 cyclins play a key role in initiating the mitotic cell cycle, entry into meiosis depends on Ime1, a transcriptional activator regulated by both nutritional and cell-type signals. We show here that G1 cyclins downregulate IME1 transcription and prevent the accumulation of the Ime1 protein within the nucleus, which results in repression of early-meiotic gene expression. As G1-cyclin deficient cells do not require nutrient starvation to undergo meiosis, G1 cyclin would exert its role by transmitting essential nutritional signals to Ime1 function. The existence of a negative cross-talk mechanism between mitosis and meiosis may help explain why these two developmental options are incompatible in budding yeast.
|Status: Published||Type: Journal Article||PubMed ID: 9889189|
Topics addressed in this paper
Number of different genes curated to this paper: 7
- To go to the Locus page for a gene, click on the gene name.
|Cell Cycle Phase Involved|
|Fungal Related Genes/Proteins|
|RNA Levels and Processing|