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Bertram PG, et al.  (2000) Tripartite regulation of Gln3p by TOR, Ure2p, and phosphatases. J Biol Chem 275(46):35727-33

Abstract: Gln3p is a GATA-type transcription factor responsive to different nitrogen nutrients and starvation in yeast Saccharomyces cerevisiae. Recent evidence has linked TOR signaling to Gln3p. Rapamycin causes dephosphorylation and nuclear translocation of Gln3p, thereby activating nitrogen catabolite repressible-sensitive genes. However, a detailed mechanistic understanding of this process is lacking. In this study, we show that Tor1p physically interacts with Gln3p. An intact TOR kinase domain is essential for the phosphorylation of Gln3p, inhibition of Gln3p nuclear entry and repression of Gln3p-dependent transcription. In contrast, at least two distinct protein phosphatases, Pph3p and the Tap42p-dependent phosphatases, are involved in the activation of Gln3p. The yeast pro-prion protein Ure2p binds to both hyper- and hypo-phosphorylated Gln3p. In contrast to the free Gln3p, the Ure2p-bound Gln3p is signifcantly resistant to dephosphorylation. Taken together, these results reveal a tripartite regulatory mechanism by which the phosphorylation of Gln3p is regulated.

Status: Published Type: Journal Article PubMed ID: 10940301

Topics addressed in this paper

Number of different genes curated to this paper: 40

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Topics Genes linked to topics (#1 - 10 )
AGP1 APE2 ARG1 ARG4 ARO10 ARO9 ASP3-1 ASP3-2 ASP3-3 ASP3-4
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Topics Genes linked to topics (#11 - 20 )
BAT2 CAN1 CAR1 CPS1 DAL2 DAL3 DAL5 DAL7 DAL81 DAL82
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Topics Genes linked to topics (#21 - 30 )
DIP5 DUR3 GAP1 GAT1 GDH1 GDH2 GLN3 GZF3 IRC7 LYS1
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Topics Genes linked to topics (#31 - 40 )
LYS21 PPH3 PRR2 TAP42 TOR1 UGA1 UGA3 UGA4 URE2 YBR139W
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