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Li XY, et al.  (2000) Distinct classes of yeast promoters revealed by differential TAF recruitment. Science 288(5469):1242-4

Abstract: The transcription factor TFIID contains the TATA box binding protein (TBP) and multiple TBP-associated factors (TAFs). Here, the association of TFIID components with promoters that either are dependent on multiple TAFs (TAFdep) or have no apparent TAF requirement (TAFind) is analyzed in yeast. At TAFdep promoters, TAFs are present at levels comparable to that of TBP, whereas at TAFind promoters, TAFs are present at levels that approximate background. After inactivation of several general transcription factors, including TBP, TAFs are still recruited by activators to TAFdep promoters. The results reveal two classes of promoters: at TAFind promoters, TBP is recruited in the apparent absence of TAFs, whereas at TAFdep promoters, TAFs are co-recruited with TBP in a manner consistent with direct activator-TAF interactions.

Status: Published Type: Journal Article PubMed ID: 10817999

Topics addressed in this paper

Number of different genes curated to this paper: 18

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Topics Genes linked to topics (#1 - 10 )
ACT1 ADH1 CUP1-1 CUP1-2 GAL1 PGK1 RPL25 RPS30A RPS30B RPS5
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Topics Genes linked to topics (#11 - 18 )
SED1 SPT15 SSB1 TAF1 TAF10 TAF12 TAF6 TAF9
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