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Voss H, et al.  (1997) DNA sequencing and analysis of 130 kb from yeast chromosome XV. Yeast 13(7):655-72

Abstract: We have determined the nucleotide sequence of 129,524 bases of yeast (Saccharomyces cerevisiae) chromosome XV. Sequence analysis revealed the presence of 59 non-overlapping open reading frames (ORFs) of length > 300 bp, three tRNA genes, four delta elements and one Ty-element. Among the 21 previously known yeast genes (36% of all ORFs in this fragment) were nucleoporin (NUP1), ras protein (RAS1), RNA polymerase III (RPC1) and elongation factor 2 (EF2). Further, 31 ORFs (53% of the total) were found to be homologous to known protein or DNA sequences, or sequence patterns. For seven ORFs (11% of the total) no homology was found. Among the most interesting protein identification in this DNA fragment are an inositol polyphosphatase, the second gene of this type found in yeast (homologous to the human OCRL gene involved in Lowe's syndrome), a new ADP ribosylation factor of the arf6 subfamily, the first protein containing three C2 domains, and an ORF similar to a Bacillus subtilis cell-cycle related protein. For each ORF detailed sequence analysis was carried out, with a full consideration of its biological function and pointing out key regions of interest for further functional analysis.

Status: Published Type: Journal Article PubMed ID: 9200815

Topics addressed in this paper

Number of different genes curated to this paper: 64

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Topics Genes linked to topics (#1 - 10 )
ADE2 AFI1 ARF3 ARP8 AZF1 BAG7 CAT5 CEX1 CRC1 ECM3
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Topics Genes linked to topics (#11 - 20 )
EFT1 ELG1 GCY1 IAH1 IDH2 INP53 IRC14 KTR1 LEO1 LEU9
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Topics Genes linked to topics (#21 - 30 )
LPX1 LSC1 NUP1 ORT1 OST2 OST3 PFY1 PIN2 PNO1 PTC5
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Topics Genes linked to topics (#31 - 40 )
RAS1 RGA1 RGS2 RIO1 RKI1 RPO31 RPS7A RPT5 RTC5 RUP1
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Topics Genes linked to topics (#41 - 50 )
SFL1 SIA1 TCB1 TFC7 TGL5 THI80 TMA46 TRS33 UBP2 VAM3
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Topics Genes linked to topics (#51 - 60 )
VPS17 VPS21 WHI5 YOR082C YOR093C YOR097C YOR102W YOR111W YOR114W YOR121C
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Topics Genes linked to topics (#61 - 64 )
YOR131C YOR139C YORWTy1-2 YVC1
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