SGD Paper 
Yamashita I (1993) Isolation and characterization of the SUD1 gene, which encodes a global repressor of core promoter activity in Saccharomyces cerevisiae. Mol Gen Genet 241(5-6):616-26
Abstract: The SUD1 gene was identified during a hunt for mutants that are able to express an sta1 gene (encoding an extracellular glucoamylase) lacking an upstream activation sequence (UAS) for transcription. A null allele of sud1 alleviated the transcriptional defect of the UAS-less sta1 and also suppressed mutations in trans-acting genes (GAM1/SNF2 and GAM3/ADR6) required for transcription of STA1. The mutation also increased expression from various core promoters (CYC1, CUP1, HIS3, PUT1, and PUT2), suggesting that the SUD1 protein is a global transcriptional regulator that plays a negative role at or near the TATA element. However, the SUD1 function was ineffective on promoters containing a UAS from either STA1 or GAL10 under derepressed conditions. The sud1 mutation suppressed the salt-sensitive cell growth phenotype caused by elevated levels of the TATA-binding protein (SPT15), further suggesting a transcriptional role for SUD1. sud1 cells showed additional pleiotropic phenotypes: temperature-sensitive (ts) growth, reduced efficiencies of sporulation, and sensitivity to heat shock and nitrogen starvation. The SUD1 gene is predicted to encode a 64 kDa, hydrophilic protein.
| Status: Published | Type: Journal Article | PubMed ID: 8264536 |
Topics addressed in this paper
Number of different genes curated to this paper: 10
- To find other papers on a gene and topic, click on the colored ball in the appropriate box.
- displays other papers with information about that topic for that gene.
- displays other papers in SGD that are associated with that topic.
The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
- To go to the Locus page for a gene, click on the gene name.
| Topics | Genes linked to topics | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CUP1-1 | CUP1-2 | HIS3 | PUT1 | PUT2 | SNF2 | SPT10 | SPT15 | STA1 | SWI1 | |
| Additional Literature |  | | | | | | | | | |
| Alias | | |||||||||
| Archived Literature | | | ||||||||
| Function/Process | | |||||||||
| Genetic Interactions | | | ||||||||
| Mutants/Phenotypes | | |||||||||
| Primary Literature | | |||||||||
| Protein Physical Properties | | |||||||||
| Regulation of | | | | | | |||||
| Regulatory Role | | |||||||||
| RNA Levels and Processing | | |||||||||
| Transcription | | | ||||||||
