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Lyons TJ, et al.  (2000) Genome-wide characterization of the Zap1p zinc-responsive regulon in yeast. Proc Natl Acad Sci U S A 97(14):7957-62

Abstract: The Zap1p transcription factor senses cellular zinc status and increases expression of its target genes in response to zinc deficiency. Previously known Zap1p-regulated genes encode the Zrt1p, Zrt2p, and Zrt3p zinc transporter genes and Zap1p itself. To allow the characterization of additional genes in yeast important for zinc homeostasis, a systematic study of gene expression on the genome-wide scale was used to identify other Zap1p target genes. Using a combination of DNA microarrays and a computer-assisted analysis of shared motifs in the promoters of similarly regulated genes, we identified 46 genes that are potentially regulated by Zap1p. Zap1p-regulated expression of seven of these newly identified target genes was confirmed independently by using lacZ reporter fusions, suggesting that many of the remaining candidate genes are also Zap1p targets. Our studies demonstrate the efficacy of this combined approach to define the regulon of a specific eukaryotic transcription factor.

Status: Published Type: Journal Article PubMed ID: 10884426

Topics addressed in this paper

Number of different genes curated to this paper: 46

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Topics Topics not linked to Genes Genes linked to topics (#1 - 10 )
ADE17 ADH4 BAG7 COS1 COS2 COS3 COS4 COS6 COS8 DPP1
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DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#11 - 20 )
FET4 GPG1 GRE2 ICY2 IZH1 IZH2 MCD4 MNT2 MOH1 NRG2
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DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#21 - 30 )
PEP4 PHM7 PRC1 PST1 RAD27 RRT1 RTC4 SEG1 TKL2 TPO5
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DNA/RNA Sequence Features blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Topics Genes linked to topics (#31 - 40 )
URA10 VEL1 YJL132W YJR061W YLL020C YNL234W YOL131W YOR387C ZAP1 ZIP1
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Topics Genes linked to topics (#41 - 46 )
ZPS1 ZRC1 ZRG17 ZRT1 ZRT2 ZRT3
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Function/Process blue ball blue ball blue ball
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