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Grant PA, et al.  (1998) A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation. Cell 94(1):45-53

Abstract: A number of transcriptional coactivator proteins have been identified as histone acetyltransferase (HAT) proteins, providing a direct molecular basis for the coupling of histone acetylation and transcriptional activation. The yeast Spt-Ada-Gcn5-acetyltransferase (SAGA) complex requires the coactivator protein Gcn5 for HAT activity. Identification of protein subunits by mass spectrometry and immunoblotting revealed that the TATA binding protein-associated factors (TAF(II)s) TAF(II)90, -68/61, -60, -25/23, and -20/17 are integral components of this complex. In addition, TAF(II)68 was required for both SAGA-dependent nucleosomal HAT activity and transcriptional activation from chromatin templates in vitro. These results illustrate a role for certain TAF(II) proteins in the regulation of gene expression at the level of chromatin modification that is distinct from the TFIID complex and TAF(II)145.

Status: Published Type: Journal Article PubMed ID: 9674426

Topics addressed in this paper

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Topics Genes linked to topics (#1 - 10 )
ADA2 GCN4 GCN5 HFI1 NGG1 SPT15 SPT20 SPT3 SPT7 SPT8
Additional Literature blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball
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Topics Genes linked to topics (#11 - 16 )
TAF1 TAF10 TAF12 TAF5 TAF6 TAF9
Additional Literature blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball
Other Features blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball
Regulatory Role blue ball blue ball blue ball blue ball blue ball

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