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Myers LC, et al.  (1998) The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain. Genes Dev 12(1):45-54

Abstract: Mediator was resolved from yeast as a multiprotein complex on the basis of its requirement for transcriptional activation in a fully defined system. Three groups of mediator polypeptides could be distinguished: the products of five SRB genes, identified as suppressors of carboxy-terminal domain (CTD)-truncation mutants; products of four genes identified as global repressors; and six members of a new protein family, termed Med, thought to be primarily responsible for transcriptional activation. Notably absent from the purified mediator were Srbs 8, 9, 10, and 11, as well as members of the SWI/SNF complex. The CTD was required for function of mediator in vitro, in keeping with previous indications of involvement of the CTD in transcriptional activation in vivo. Evidence for human homologs of several mediator proteins, including Med7, points to similar mechanisms in higher cells.

Status: Published Type: Journal Article PubMed ID: 9420330

Topics addressed in this paper

Number of different genes curated to this paper: 23

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Topics Genes linked to topics (#1 - 10 )
GAL11 MED1 MED11 MED2 MED4 MED6 MED7 MED8 NUT2 PGD1
Additional Literature blue ball blue ball blue ball blue ball blue ball
Alias blue ball
DNA/RNA Sequence Features blue ball blue ball blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Fungal Related Genes/Proteins blue ball blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball
Other Features blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball
Protein Physical Properties blue ball blue ball
Protein Sequence Features blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
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Techniques and Reagents blue ball blue ball blue ball blue ball

Topics Genes linked to topics (#11 - 20 )
RGR1 ROX3 RPO21 SIN4 SRB2 SRB4 SRB5 SRB6 SRB7 SRB8
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball
Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball
Protein-protein Interactions blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Techniques and Reagents blue ball

Topics Genes linked to topics (#21 - 23 )
SSN2 SSN3 SSN8
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Function/Process blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball
Techniques and Reagents blue ball blue ball blue ball

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