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Dimova D, et al.  (1999) A role for transcriptional repressors in targeting the yeast Swi/Snf complex. Mol Cell 4(1):75-83

Abstract: Genetic and biochemical studies indicate that the evolutionarily conserved Swi/Snf complex acts at a subset of genes to help transcriptional activators function on chromatin templates. The mechanism by which this complex is targeted to specific chromosomal loci remains unknown. We show that Swi/Snf is required for expression of the yeast histone HTA1-HTB1 locus because of the role of Hir1p and Hir2p corepressors in negatively regulating transcription. Snf5p, Snf2p/Swi2p, and Swi3p, three components of the yeast Swi/Snf complex, coimmunoprecipitate with each Hir protein, and Snf5p is maximally associated with the HTA1-HTB1 promoter when the Hir-based repression system is intact and the Swi/Snf complex is functional. The data support a role for the Hir repressors in the gene-specific targeting of Swi/Snf.

Status: Published Type: Journal Article PubMed ID: 10445029

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HIR1 HIR2 HTA1 HTB1 SNF2 SNF5 SWI3
Cellular Location blue ball blue ball
DNA/RNA Sequence Features blue ball blue ball
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Fungal Related Genes/Proteins blue ball blue ball blue ball
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Protein-Nucleic Acid Interactions blue ball
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