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Reifsnyder C, et al.  (1996) Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet 14(1):42-9

Abstract: Silencing is an epigenetic form of transcriptional regulation whereby genes are heritably, but not necessarily permanently, inactivated. We have identified the Saccharomyces cerevisiae genes SAS2 and SAS3 through a screen for enhancers of sir1 epigenetic silencing defects. SAS2, SAS3 and a Schizosaccharomyces pombe homologue are closely related to several human genes, including one associated with acute myeloid leukaemia arising from the recurrent translocation t(8;16)(p11;p13) and one implicated in HIV-1 Tat interactions. All of these genes encode proteins with an atypical zinc finger and well-conserved similarities to acetyltransferases. Sequence similarities and yeast mutant phenotypes suggest that SAS-like genes function in transcriptional regulation and cell-cycle exit and reveal novel connections between transcriptional silencing and human disease.

Status: Published Type: Journal Article PubMed ID: 8782818

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Topics Genes linked to topics
SAS2 SAS3 SIR1
Cell Cycle Phase Involved blue ball blue ball
Disease Gene Related blue ball blue ball blue ball
Function/Process blue ball blue ball
Fungal Related Genes/Proteins blue ball
Genetic Interactions blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball blue ball
Primary Literature blue ball blue ball blue ball
Protein Sequence Features blue ball blue ball
Protein/Nucleic Acid Structure blue ball
Regulatory Role blue ball blue ball

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