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Tadi D, et al.  (1999) Selection of genes repressed by cAMP that are induced by nutritional limitation in Saccharomyces cerevisiae. Yeast 15(16):1733-45

Abstract: DNA-lacZ fusion libraries of yeast Saccharomyces cerevisiae were used to select genes coordinately regulated by the Ras-cAMP-cAPK signalling pathway. Sixteen new genes (AGP1, APE2, APE3, FPS1, GUT2, MDH2, PLB2, PYK2, RNR3, SUR1, UGA1, YHR033w, YBR006w, YHR143w, YMR086w and YOR173w) were found to be repressed by cAMP. Most of these genes encode for metabolic enzymes and are induced by nutritional limitations. These common properties suggest a role of this pathway in the metabolic adjustment of the cell to nutritional variations. The induction of 10 of these genes is reduced in the msn2,msn4 double mutant, which emphasizes the role of the Msn2/4p transcriptional activators in mediating the Ras-cAMP-cAPK signalling pathway. The Msn2p/Msn4p-independent expression of the six other genes suggests the existence of other regulatory systems under the control of this pathway. Copyright 1999 John Wiley & Sons, Ltd.

Status: Published Type: Journal Article PubMed ID: 10590462

Topics addressed in this paper

Number of different genes curated to this paper: 18

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Topics Genes linked to topics (#1 - 10 )
AGP1 APE2 APE3 DCS2 DSE2 FPS1 GUT2 MDH2 MSN2 MSN4
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Topics Genes linked to topics (#11 - 18 )
PLB2 PYK2 RNR3 SEG1 SUR1 UGA1 UGA2 YHR033W
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Function/Process blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball
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