SGD Paper 
Hegner J, et al. (1999) Ligand recognition in multiallelic pheromone receptors from the basidiomycete Schizophyllum commune studied in yeast. Fungal Genet Biol 26(3):190-7
Abstract: The homobasidiomycete Schizophyllum commune encodes a multiallelic pheromone receptor system that distinguishes more than 20 nonself from at least 2 self pheromones. The well-investigated pheromone response system of the yeast Saccharomyces cerevisiae was used to link the FUS1::lacZ reporter system to the heterologous pheromone receptors from S. commune. To investigate yeast G-protein binding, the unchanged heterologous receptor was compared to constructs carrying an exchange of the 3rd cytoplasmatic loop for the Ste2 sequence. A better coupling could be achieved with the altered constructs. In order to examine activation by single pheromones, an artificial peptide based on the sequence of a new putative pheromone gene, bap2(1), in the Balpha2 mating-type locus encoding the shortest pheromone found so far in fungal mating types was used. Thus, we have reassembled the pheromone recognition of the basidiomycete S. commune and constructed a system ideal for specificity analysis in the yeast S. cerevisiae. Copyright 1999 Academic Press.
| Status: Published | Type: Journal Article | PubMed ID: 10361033 |
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| Topics | Genes linked to topics |
|---|---|
| STE2 | |
| Fungal Related Genes/Proteins |  |
| Primary Literature | |
| Protein Sequence Features | |
| Techniques and Reagents | |
