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Tollervey D  (1987) A yeast small nuclear RNA is required for normal processing of pre-ribosomal RNA. EMBO J 6(13):4169-75

Abstract: In Saccharomyces cerevisiae, seven snRNAs (snR3, 4, 5, 8, 9, 10 and 17) are retained in the nucleus under conditions in which nucleoplasmic RNAs are lost, and may be nucleolar. All of these snRNAs show properties consistent with hydrogen bonding to pre-ribosomal RNAs; snR5 and 8 with 20S pre-rRNA, snR3, 4, 10 and 17 with 35S pre-rRNA and snR9 with 20-35S RNA. Strains lacking snR10 are impaired in growth and specifically defective in the processing of 35S RNA. Processing is slowed, leading to 35S RNA accumulation and most cleavage occurs, not at the normal sites, but at sites which in wild-type strains are used for subsequent steps in rRNA maturation.

Status: Published Type: Journal Article PubMed ID: 3327689

Topics addressed in this paper

Number of different genes curated to this paper: 16

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Topics Genes linked to topics (#1 - 10 )
RDN18-1 RDN18-2 RDN25-1 RDN25-2 RDN37-1 RDN37-2 RDN58-1 RDN58-2 SNR10 SNR17A
Additional Literature blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Cellular Location blue ball blue ball
Function/Process blue ball
Mutants/Phenotypes blue ball
Nucleic Acid Interaction blue ball blue ball
Primary Literature blue ball blue ball
RNA Levels and Processing blue ball blue ball blue ball blue ball blue ball blue ball blue ball blue ball
Strains/Constructs blue ball

Topics Genes linked to topics (#11 - 16 )
SNR17B SNR3 SNR4 SNR5 SNR8 SNR9
Cellular Location blue ball blue ball blue ball blue ball blue ball blue ball
Nucleic Acid Interaction blue ball blue ball blue ball blue ball blue ball blue ball
Primary Literature blue ball blue ball blue ball blue ball blue ball blue ball

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