SGD Paper Help


Page Contents:
Yoshida S, et al.  (1995) STT10, a novel class-D VPS yeast gene required for osmotic integrity related to the PKC1/STT1 protein kinase pathway. Gene 160(1):117-22

Abstract: We report the genetic and biochemical properties of a staurosporine (ST)- and temperature-sensitive mutant, stt10, of Saccharomyces cerevisiae. The stt10 mutant shows an osmoremedial phenotype in a medium with 1 M sorbitol. ST sensitivity of the stt10 mutant was suppressed by overexpression of PKC1/STT1, showing the genetic interactions of STT10 with the PKC1/STT1 pathway. The nucleotide sequence of STT10 predicts a hydrophilic protein composed of 577 amino acids that possesses 20-25% sequence similarity with yeast Slp1/Vam5p, Sec1p and Sly1p, and nematode Unc-18. The stt10 deletion mutant is viable and shows a typical class-D vacuolar protein sorting defective (vps) phenotype. Vacuoles from stt10 cells have a normal vacuolar H(+)-ATPase activity, but are defective in vacuolar acidification. Genetic studies of yeast mutants carrying delta stt10, delta bck1, stt1/pkc1 or stt4 have revealed that their functions are phenotypically related to maintenance of cellular osmotic integrity.

Status: Published Type: Journal Article PubMed ID: 7628704

Topics addressed in this paper

Number of different genes curated to this paper: 7

  • To find other papers on a gene and topic, click on the colored ball in the appropriate box.
  • displays other papers with information about that topic for that gene.
  • displays other papers in SGD that are associated with that topic.
    The topic is addressed in these papers but does not describe a specific gene or chromosomal feature.
  • To go to the Locus page for a gene, click on the gene name.
Topics Genes linked to topics
BCK1 PKC1 SEC1 SLY1 STT4 VPS33 VPS45
Additional Literature blue ball blue ball blue ball blue ball
Alias blue ball blue ball
Archived Literature blue ball
DNA/RNA Sequence Features blue ball
Function/Process blue ball blue ball
Fungal Related Genes/Proteins blue ball blue ball blue ball
Genetic Interactions blue ball blue ball blue ball
Mutants/Phenotypes blue ball blue ball blue ball
Non-Fungal Related Genes/Proteins blue ball
Primary Literature blue ball blue ball blue ball
Protein Sequence Features blue ball
Strains/Constructs blue ball blue ball blue ball

Author Searches

To find contact information or other publications by the authors of this paper, follow these three steps:
  1. (1) Choose an author,
  2. (2) Choose a search parameter,
  3. (3) Click to implement
Page Contents: