XRN1/YGL173C Literature Guide Help

Other names published for XRN1: DST2, RAR5, SEP1, SKI1, KEM1, YGL173C

XRN1 - Substrates/Ligands/Cofactors (29)

ReferenceOther Genes Addressed
Egecioglu DE, et al.  (2012) Quality control of MATa1 splicing and exon skipping by nuclear RNA degradation. Nucleic Acids Res 40(4):1787-96
Sinturel F, et al.  (2012) Activation of 5'-3' exoribonuclease Xrn1 by cofactor Dcs1 is essential for mitochondrial function in yeast. Proc Natl Acad Sci U S A 109(21):8264-9
Whipple JM, et al.  (2011) The yeast rapid tRNA decay pathway primarily monitors the structural integrity of the acceptor and T-stems of mature tRNA. Genes Dev 25(11):1173-84
Wilusz JE, et al.  (2011) tRNAs marked with CCACCA are targeted for degradation. Science 334(6057):817-21
Fujimura T and Esteban R  (2010) Yeast double-stranded RNA virus L-A deliberately synthesizes RNA transcripts with 5'-diphosphate. J Biol Chem 285(30):22911-8
Gallego O, et al.  (2010) A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Mol Syst Biol 6():430
Jaag HM and Nagy PD  (2009) Silencing of Nicotiana benthamiana Xrn4p exoribonuclease promotes tombusvirus RNA accumulation and recombination. Virology 386(2):344-52
Sinturel F, et al.  (2009) Real-time fluorescence detection of exoribonucleases. RNA 15(11):2057-62
Meaux S and Van Hoof A  (2006) Yeast transcripts cleaved by an internal ribozyme provide new insight into the role of the cap and poly(A) tail in translation and mRNA decay. RNA 12(7):1323-37
Pathak R, et al.  (2005) A role for KEM1 at the START of the cell cycle in Saccharomyces cerevisiae. Curr Genet 48(5):300-9
Zer C and Chanfreau G  (2005) Regulation and surveillance of normal and 3'-extended forms of the yeast aci-reductone dioxygenase mRNA by RNase III cleavage and exonucleolytic degradation. J Biol Chem 280(32):28997-9003
He F and Jacobson A  (2001) Upf1p, Nmd2p, and Upf3p regulate the decapping and exonucleolytic degradation of both nonsense-containing mRNAs and wild-type mRNAs. Mol Cell Biol 21(5):1515-30
Jungwirth H, et al.  (2001) Diazaborine treatment of Baker's yeast results in stabilization of aberrant mRNAs. J Biol Chem 276(39):36419-24
van Beekvelt CA, et al.  (2001) Identification of cis-acting elements involved in 3'-end formation of Saccharomyces cerevisiae 18S rRNA. RNA 7(6):896-903
Geerlings TH, et al.  (2000) The final step in the formation of 25S rRNA in Saccharomyces cerevisiae is performed by 5'-->3' exonucleases. RNA 6(12):1698-703
Muniyappa K, et al.  (2000) Yeast meiosis-specific protein Hop1 binds to G4 DNA and promotes its formation. Mol Cell Biol 20(4):1361-9
Solinger JA, et al.  (1999) Active-site mutations in the Xrn1p exoribonuclease of Saccharomyces cerevisiae reveal a specific role in meiosis. Mol Cell Biol 19(9):5930-42
Zhang Z, et al.  (1998) Strand exchange protein 1 (Sep1) from Saccharomyces cerevisiae does not promote branch migration in vitro. J Biol Chem 273(9):4950-6
Poole TL and Stevens A  (1997) Structural modifications of RNA influence the 5' exoribonucleolytic hydrolysis by XRN1 and HKE1 of Saccharomyces cerevisiae. Biochem Biophys Res Commun 235(3):799-805
Yun DF and Sherman F  (1996) Degradation of CYC1 mRNA in the yeast Saccharomyces cerevisiae does not require translation. Proc Natl Acad Sci U S A 93(17):8895-900
Liu Z, et al.  (1995) Gene disruption of a G4-DNA-dependent nuclease in yeast leads to cellular senescence and telomere shortening. Proc Natl Acad Sci U S A 92(13):6002-6
Poole TL and Stevens A  (1995) Comparison of features of the RNase activity of 5'-exonuclease-1 and 5'-exonuclease-2 of Saccharomyces cerevisiae. Nucleic Acids Symp Ser (33):79-81
Stevens A and Poole TL  (1995) 5'-exonuclease-2 of Saccharomyces cerevisiae. Purification and features of ribonuclease activity with comparison to 5'-exonuclease-1. J Biol Chem 270(27):16063-9
Johnson AW and Kolodner RD  (1994) The activity of the Saccharomyces cerevisiae strand exchange protein 1 intrinsic exonuclease during joint molecule formation. J Biol Chem 269(5):3664-72
Liu Z and Gilbert W  (1994) The yeast KEM1 gene encodes a nuclease specific for G4 tetraplex DNA: implication of in vivo functions for this novel DNA structure. Cell 77(7):1083-92
Muhlrad D, et al.  (1994) Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript. Genes Dev 8(7):855-66
Liu Z, et al.  (1993) Identification and characterization of a nuclease activity specific for G4 tetrastranded DNA. Proc Natl Acad Sci U S A 90(8):3157-61
Johnson AW and Kolodner RD  (1991) Strand exchange protein 1 from Saccharomyces cerevisiae. A novel multifunctional protein that contains DNA strand exchange and exonuclease activities. J Biol Chem 266(21):14046-54
Stevens A  (1979) Evidence for a 5' leads to 3' direction of hydrolysis by a 5' mononucleotide-producing exoribonuclease from Saccharomyces cerevisiae. Biochem Biophys Res Commun 86(4):1126-32