VDE Literature Guide Help

Other names published for VDE: YDL184w-a, VDE1, YDL185W2, PI-SceI

VDE - Substrates/Ligands/Cofactors (23)

ReferenceOther Genes Addressed
Barzel A, et al.  (2011) Native homing endonucleases can target conserved genes in humans and in animal models. Nucleic Acids Res 39(15):6646-59
Senejani AG and Gogarten JP  (2007) Structural stability and endonuclease activity of a PI-SceI GFP-fusion protein. Int J Biol Sci 3(4):205-11
Steuer S, et al.  (2004) Chimeras of the homing endonuclease PI-SceI and the homologous Candida tropicalis intein: a study to explore the possibility of exchanging DNA-binding modules to obtain highly specific endonucleases with altered specificity. Chembiochem 5(2):206-13
Gimble FS, et al.  (2003) Assessing the plasticity of DNA target site recognition of the PI-SceI homing endonuclease using a bacterial two-hybrid selection system. J Mol Biol 334(5):993-1008
Miyake T, et al.  (2003) Involvement of the VDE homing endonuclease and rapamycin in regulation of the Saccharomyces cerevisiae GSH11 gene encoding the high affinity glutathione transporter. J Biol Chem 278(41):39632-6
Nogami S, et al.  (2002) Homing at an extragenic locus mediated by VDE (PI-SceI) in Saccharomyces cerevisiae. Yeast 19(9):773-82
Werner E, et al.  (2002) High resolution crystal structure of domain I of the Saccharomyces cerevisiae homing endonuclease PI-SceI. Nucleic Acids Res 30(18):3962-71
Gimble FS  (2001) Degeneration of a homing endonuclease and its target sequence in a wild yeast strain. Nucleic Acids Res 29(20):4215-23
Christ F, et al.  (2000) A model for the PI-SceIxDNA complex based on multiple base and phosphate backbone-specific photocross-links. J Mol Biol 300(4):867-75
Hu D, et al.  (2000) Probing the structure of the PI-SceI-DNA complex by affinity cleavage and affinity photocross-linking. J Biol Chem 275(4):2705-12
Christ F, et al.  (1999) The monomeric homing endonuclease PI-SceI has two catalytic centres for cleavage of the two strands of its DNA substrate. EMBO J 18(24):6908-16
Hu D, et al.  (1999) Mapping of a DNA binding region of the PI-sceI homing endonuclease by affinity cleavage and alanine-scanning mutagenesis. Biochemistry 38(39):12621-8
Miyamoto S, et al.  (1999) Recognition and cleavage of double-stranded DNA by yeast VMA1-derived endonuclease. Nucleic Acids Symp Ser (42):197-8
Pingoud V, et al.  (1999) Photocross-linking of the homing endonuclease PI-SceI to its recognition sequence. J Biol Chem 274(15):10235-43
Grindl W, et al.  (1998) The protein splicing domain of the homing endonuclease PI-sceI is responsible for specific DNA binding. Nucleic Acids Res 26(8):1857-62
Nahon E and Raveh D  (1998) Targeting a truncated Ho-endonuclease of yeast to novel DNA sites with foreign zinc fingers. Nucleic Acids Res 26(5):1233-9
Pingoud V, et al.  (1998) Structural and functional analysis of the homing endonuclease PI-sceI by limited proteolytic cleavage and molecular cloning of partial digestion products. Biochemistry 37(22):8233-43
Gimble FS and Wang J  (1996) Substrate recognition and induced DNA distortion by the PI-SceI endonuclease, an enzyme generated by protein splicing. J Mol Biol 263(2):163-80
Wende W, et al.  (1996) Binding, bending and cleavage of DNA substrates by the homing endonuclease Pl-SceI. Nucleic Acids Res 24(21):4123-32
Gimble FS and Stephens BW  (1995) Substitutions in conserved dodecapeptide motifs that uncouple the DNA binding and DNA cleavage activities of PI-SceI endonuclease. J Biol Chem 270(11):5849-56
Gimble FS and Thorner J  (1993) Purification and characterization of VDE, a site-specific endonuclease from the yeast Saccharomyces cerevisiae. J Biol Chem 268(29):21844-53
Bremer MC, et al.  (1992) VDE endonuclease cleaves Saccharomyces cerevisiae genomic DNA at a single site: physical mapping of the VMA1 gene. Nucleic Acids Res 20(20):5484
Gimble FS and Thorner J  (1992) Homing of a DNA endonuclease gene by meiotic gene conversion in Saccharomyces cerevisiae. Nature 357(6376):301-6