TOP2/YNL088W Literature Guide Help

Other names published for TOP2: TOR3, TRF3, DNA topoisomerase 2, YNL088W

TOP2 - Substrates/Ligands/Cofactors (55)

Results: 1 - 30 of 55 records
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ReferenceOther Genes Addressed
Hasinoff BB, et al.  (2012) The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II. Biochem Pharmacol 84(12):1617-26
Schmidt BH, et al.  (2012) Structure of a topoisomerase II-DNA-nucleotide complex reveals a new control mechanism for ATPase activity. Nat Struct Mol Biol 19(11):1147-54
Baxter J, et al.  (2011) Positive supercoiling of mitotic DNA drives decatenation by topoisomerase II in eukaryotes. Science 331(6022):1328-32
Schmidt BH, et al.  (2010) A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature 465(7298):641-4
Bermejo R, et al.  (2009) Genome-organizing factors Top2 and Hmo1 prevent chromosome fragility at sites of S phase transcription. Cell 138(5):870-84
Mueller-Planitz F and Herschlag D  (2008) Coupling between ATP binding and DNA cleavage by DNA topoisomerase II: A unifying kinetic and structural mechanism. J Biol Chem 283(25):17463-76
Wilstermann AM, et al.  (2007) Topoisomerase II - drug interaction domains: identification of substituents on etoposide that interact with the enzyme. Biochemistry 46(28):8217-25
Mueller-Planitz F and Herschlag D  (2006) Interdomain communication in DNA topoisomerase II. DNA binding and enzyme activation. J Biol Chem 281(33):23395-404
Rupesh KR, et al.  (2006) Synthesis, characterization and in vitro biological activity studies of Cu-M (M=Cu(2+), Co(2+), Ni(2+), Mn(2+), Zn(2+)) bimetallic complexes. Eur J Med Chem 41(12):1494-503
de Mejia EG, et al.  (2006) Catalytic inhibition of human DNA topoisomerase by phenolic compounds in Ardisia compressa extracts and their effect on human colon cancer cells. Food Chem Toxicol 44(8):1191-203
Moro S, et al.  (2004) Interaction model for anthracycline activity against DNA topoisomerase II. Biochemistry 43(23):7503-13
Trigueros S, et al.  (2004) Asymmetric removal of supercoils suggests how topoisomerase II simplifies DNA topology. J Mol Biol 335(3):723-31
Classen S, et al.  (2003) Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187. Proc Natl Acad Sci U S A 100(19):10629-34
Mondal N, et al.  (2003) Elongation by RNA polymerase II on chromatin templates requires topoisomerase activity. Nucleic Acids Res 31(17):5016-24
Vilain N, et al.  (2003) Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalpha. Nucleic Acids Res 31(19):5714-22
Bachant J, et al.  (2002) The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell 9(6):1169-82
Baird CL, et al.  (2001) The ATPase reaction cycle of yeast DNA topoisomerase II. Slow rates of ATP resynthesis and P(i) release. J Biol Chem 276(30):27893-8
Roca J  (2001) Varying levels of positive and negative supercoiling differently affect the efficiency with which topoisomerase II catenates and decatenates DNA. J Mol Biol 305(3):441-50
Wang H, et al.  (2001) Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation. Biochemistry 40(11):3316-23
Jensen LH, et al.  (2000) A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines. J Biol Chem 275(3):2137-46
Joy KL, et al.  (2000) Effect of Picrorrhiza kurroa extract on transplanted tumours and chemical carcinogenesis in mice. J Ethnopharmacol 71(1-2):261-6
Mizushina Y, et al.  (2000) Structural homology between DNA binding sites of DNA polymerase beta and DNA topoisomerase II. J Mol Biol 304(3):385-95
Morris SK, et al.  (2000) Steady-state and rapid kinetic analysis of topoisomerase II trapped as the closed-clamp intermediate by ICRF-193. J Biol Chem 275(4):2613-8
Baird CL, et al.  (1999) Topoisomerase II drives DNA transport by hydrolyzing one ATP. Proc Natl Acad Sci U S A 96(24):13685-90
Burden DA and Osheroff N  (1999) In vitro evolution of preferred topoisomerase II DNA cleavage sites. J Biol Chem 274(8):5227-35
Morris SK and Lindsley JE  (1999) Yeast topoisomerase II is inhibited by etoposide after hydrolyzing the first ATP and before releasing the second ADP. J Biol Chem 274(43):30690-6
Morris SK, et al.  (1999) Kinetic and thermodynamic analysis of mutant type II DNA topoisomerases that cannot covalently cleave DNA. J Biol Chem 274(6):3446-52
Olland S and Wang JC  (1999) Catalysis of ATP hydrolysis by two NH(2)-terminal fragments of yeast DNA topoisomerase II. J Biol Chem 274(31):21688-94
Schultz MC  (1999) Chromatin assembly in yeast cell-free extracts. Methods 17(2):161-72
Strumberg D, et al.  (1999) Molecular analysis of yeast and human type II topoisomerases. Enzyme-DNA and drug interactions. J Biol Chem 274(40):28246-55
Results: 1 - 30 of 55 records
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