RAD53/YPL153C Literature Guide Help

Other names published for RAD53: LSD1, MEC2, SPK1, YPL153C

RAD53 - Substrates/Ligands/Cofactors (34)

ReferenceOther Genes Addressed
Chen SH, et al.  (2010) A proteome-wide analysis of kinase-substrate network in the DNA damage response. J Biol Chem 285(17):12803-12
Janke R, et al.  (2010) A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae. Nucleic Acids Res 38(7):2302-13
Mok J, et al.  (2010) Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal 3(109):ra12
Palou G, et al.  (2010) Cyclin regulation by the s phase checkpoint. J Biol Chem 285(34):26431-40
Zegerman P and Diffley JF  (2010) Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation. Nature 467(7314):474-8
Truman AW, et al.  (2009) Mechanism of Mpk1 mitogen-activated protein kinase binding to the Swi4 transcription factor and its regulation by a novel caffeine-induced phosphorylation. Mol Cell Biol 29(24):6449-61
Usui T, et al.  (2009) Maintenance of the DNA-damage checkpoint requires DNA-damage-induced mediator protein oligomerization. Mol Cell 33(2):147-59
Zhang T, et al.  (2009) DNA damage checkpoint maintains CDH1 in an active state to inhibit anaphase progression. Dev Cell 17(4):541-51
Lee H, et al.  (2008) Diphosphothreonine-specific interaction between an SQ/TQ cluster and an FHA domain in the Rad53-Dun1 kinase cascade. Mol Cell 30(6):767-78
Chen SH, et al.  (2007) Mechanism of Dun1 activation by Rad53 phosphorylation in Saccharomyces cerevisiae. J Biol Chem 282(2):986-95
Bashkirov VI, et al.  (2006) DNA damage-induced phosphorylation of Rad55 protein as a sentinel for DNA damage checkpoint activation in S. cerevisiae. Methods Enzymol 409:166-82
Chin JK, et al.  (2006) Esc4/Rtt107 and the control of recombination during replication. DNA Repair (Amst) 5(5):618-28
Herzberg K, et al.  (2006) Phosphorylation of Rad55 on serines 2, 8, and 14 is required for efficient homologous recombination in the recovery of stalled replication forks. Mol Cell Biol 26(22):8396-409
Ptacek J, et al.  (2005) Global analysis of protein phosphorylation in yeast. Nature 438(7068):679-84
Agarwal R, et al.  (2003) Two distinct pathways for inhibiting pds1 ubiquitination in response to DNA damage. J Biol Chem 278(45):45027-33
Brinkworth RI, et al.  (2003) Structural basis and prediction of substrate specificity in protein serine/threonine kinases. Proc Natl Acad Sci U S A 100(1):74-9
Lopes M, et al.  (2003) Branch migrating sister chromatid junctions form at replication origins through Rad51/Rad52-independent mechanisms. Mol Cell 12(6):1499-510
Schwartz MF, et al.  (2003) FHA domain-mediated DNA checkpoint regulation of Rad53. Cell Cycle 2(4):384-96
Sidorova JM and Breeden LL  (2003) Rad53 checkpoint kinase phosphorylation site preference identified in the Swi6 protein of Saccharomyces cerevisiae. Mol Cell Biol 23(10):3405-16
Kim EM, et al.  (2002) Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase. Nucleic Acids Res 30(3):643-8
Leroy C, et al.  (2001) Silent repair accounts for cell cycle specificity in the signaling of oxidative DNA lesions. EMBO J 20(11):2896-906
Tercero JA and Diffley JF  (2001) Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint. Nature 412(6846):553-7
Wang Y, et al.  (2001) Antitumor drug adozelesin differentially affects active and silent origins of DNA replication in yeast checkpoint kinase mutants. Cancer Res 61(9):3787-94
Bashkirov VI, et al.  (2000) DNA repair protein Rad55 is a terminal substrate of the DNA damage checkpoints. Mol Cell Biol 20(12):4393-404
Durocher D, et al.  (2000) The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol Cell 6(5):1169-82
Frei C and Gasser SM  (2000) The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev 14(1):81-96
Kihara M, et al.  (2000) Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells. Its protein kinase activity is regulated by Rad53p. J Biol Chem 275(45):35051-62
Liao H, et al.  (2000) Structure of the FHA1 domain of yeast Rad53 and identification of binding sites for both FHA1 and its target protein Rad9. J Mol Biol 304(5):941-51
Simon JA, et al.  (2000) Differential toxicities of anticancer agents among DNA repair and checkpoint mutants of Saccharomyces cerevisiae. Cancer Res 60(2):328-33
Zhu H, et al.  (2000) Analysis of yeast protein kinases using protein chips. Nat Genet 26(3):283-9