GCN2/YDR283C Literature Guide Help

Other names published for GCN2: AAS1, NDR2, AAS102, YDR283C

GCN2 - Substrates/Ligands/Cofactors (17)

ReferenceOther Genes Addressed
Fasolo J, et al.  (2011) Diverse protein kinase interactions identified by protein microarrays reveal novel connections between cellular processes. Genes Dev 25(7):767-78
Gallego O, et al.  (2010) A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Mol Syst Biol 6():430
Mok J, et al.  (2010) Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci Signal 3(109):ra12
Moravcevic K, et al.  (2010) Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. Cell 143(6):966-77
Zaborske JM, et al.  (2009) Genome-wide Analysis of tRNA Charging and Activation of the eIF2 Kinase Gcn2p. J Biol Chem 284(37):25254-67
Dey M, et al.  (2005) PKR and GCN2 kinases and guanine nucleotide exchange factor eukaryotic translation initiation factor 2B (eIF2B) recognize overlapping surfaces on eIF2alpha. Mol Cell Biol 25(8):3063-75
Narasimhan J, et al.  (2004) Dimerization is required for activation of eIF2 kinase Gcn2 in response to diverse environmental stress conditions. J Biol Chem 279(22):22820-32
Kubota H, et al.  (2003) Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2. J Biol Chem 278(23):20457-60
van den Heuvel J, et al.  (1995) The highly acidic C-terminal region of the yeast initiation factor subunit 2 alpha (eIF-2 alpha) contains casein kinase phosphorylation sites and is essential for maintaining normal regulation of GCN4. Biochim Biophys Acta 1261(3):337-48
Diallinas G and Thireos G  (1994) Genetic and biochemical evidence for yeast GCN2 protein kinase polymerization. Gene 143(1):21-7
Vazquez de Aldana CR, et al.  (1994) Multicopy tRNA genes functionally suppress mutations in yeast eIF-2 alpha kinase GCN2: evidence for separate pathways coupling GCN4 expression to unchanged tRNA. Mol Cell Biol 14(12):7920-32
Marton MJ, et al.  (1993) GCN1, a translational activator of GCN4 in Saccharomyces cerevisiae, is required for phosphorylation of eukaryotic translation initiation factor 2 by protein kinase GCN2. Mol Cell Biol 13(6):3541-56
Rolfes RJ and Hinnebusch AG  (1993) Translation of the yeast transcriptional activator GCN4 is stimulated by purine limitation: implications for activation of the protein kinase GCN2. Mol Cell Biol 13(8):5099-111
Vazquez de Aldana CR, et al.  (1993) Mutations in the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2 alpha) that overcome the inhibitory effect of eIF-2 alpha phosphorylation on translation initiation. Proc Natl Acad Sci U S A 90(15):7215-9
Dever TE, et al.  (1992) Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast. Cell 68(3):585-96
Ramirez M, et al.  (1992) Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases. Mol Cell Biol 12(12):5801-15
Wek RC, et al.  (1990) Identification of positive-acting domains in GCN2 protein kinase required for translational activation of GCN4 expression. Mol Cell Biol 10(6):2820-31