SIR2/YDL042C Literature Guide Help

Other names published for SIR2: MAR1, YDL042C

SIR2 - Substrates/Ligands/Cofactors (47)

Results: 31 - 47 of 47 records
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ReferenceOther Genes Addressed
Hirao M, et al.  (2003) Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast. J Biol Chem 278(52):52773-82
Howitz KT, et al.  (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425(6954):191-6
Jackson MD, et al.  (2003) Mechanism of nicotinamide inhibition and transglycosidation by Sir2 histone/protein deacetylases. J Biol Chem 278(51):50985-98
Sauve AA and Schramm VL  (2003) Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry 42(31):9249-56
Garcia SN and Pillus L  (2002) A unique class of conditional sir2 mutants displays distinct silencing defects in Saccharomyces cerevisiae. Genetics 162(2):721-36
Robyr D, et al.  (2002) Microarray deacetylation maps determine genome-wide functions for yeast histone deacetylases. Cell 109(4):437-46
Sandmeier JJ, et al.  (2002) Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway. Genetics 160(3):877-89
Bedalov A, et al.  (2001) Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A 98(26):15113-8
Grozinger CM, et al.  (2001) Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. J Biol Chem 276(42):38837-43
Perrod S, et al.  (2001) A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast. EMBO J 20(1-2):197-209
Sauve AA, et al.  (2001) Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions. Biochemistry 40(51):15456-63
Tanny JC and Moazed D  (2001) Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product. Proc Natl Acad Sci U S A 98(2):415-20
Imai S, et al.  (2000) Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403(6771):795-800
Landry J, et al.  (2000) Role of NAD(+) in the deacetylase activity of the SIR2-like proteins. Biochem Biophys Res Commun 278(3):685-90
Landry J, et al.  (2000) The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A 97(11):5807-11
Tanner KG, et al.  (2000) Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci U S A 97(26):14178-82
Tanny JC, et al.  (1999) An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing. Cell 99(7):735-45
Results: 31 - 47 of 47 records
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