ERG7/YHR072W Literature Guide Help

Other names published for ERG7: lanosterol synthase ERG7, YHR072W

ERG7 - Substrates/Ligands/Cofactors (20)

ReferenceOther Genes Addressed
Chang CH, et al.  (2012) The cysteine 703 to isoleucine or histidine mutation of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae generates an iridal-type triterpenoid. Biochimie 94(11):2376-81
Liu YT, et al.  (2012) Protein engineering of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase into parkeol synthase. Org Lett 14(20):5222-5
Oliaro-Bosso S, et al.  (2011) Characterization of the channel constriction allowing the access of the substrate to the active site of yeast oxidosqualene cyclase. PLoS One 6(7):e22134
Wallace IM, et al.  (2011) Compound prioritization methods increase rates of chemical probe discovery in model organisms. Chem Biol 18(10):1273-83
Wu TK, et al.  (2011) Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17alpha/beta-exocyclic side chain stereochemistry. Org Biomol Chem 9(4):1092-7
Li X, et al.  (2010) Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses. Cell 143(4):639-50
Wu TK, et al.  (2010) Alteration of the Substrate's Prefolded Conformation and Cyclization Stereochemistry of Oxidosqualene-Lanosterol Cyclase of Saccharomyces cerevisiae by Substitution at Phenylalanine 699. Org Lett 12(3):500-3
Balliano G, et al.  (2009) Oxidosqualene cyclase from Saccharomyces cerevisiae, Trypanosoma cruzi, Pneumocystis carinii and Arabidopsis thaliana expressed in yeast: a model for the development of novel antiparasitic agents. Bioorg Med Chem Lett 19(3):718-23
Wu TK, et al.  (2008) Importance of Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase Tyrosine 707 Residue for Chair-Boat Bicyclic Ring Formation and Deprotonation Reactions. Org Lett 10(21):4959-62
Oliaro-Bosso S, et al.  (2007) Inhibitory effect of umbelliferone aminoalkyl derivatives on oxidosqualene cyclases from S. cerevisiae, T. cruzi, P. carinii, H. sapiens, and A. thaliana: a structure-activity study. ChemMedChem 2(2):226-33
Wu TK, et al.  (2006) Site-Saturated Mutagenesis of Histidine 234 of Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase Demonstrates Dual Functions in Cyclization and Rearrangement Reactions. J Am Chem Soc 128(19):6414-9
Germann M, et al.  (2005) Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis. J Biol Chem 280(43):35904-13
Oliaro-Bosso S, et al.  (2004) Umbelliferone aminoalkyl derivatives as inhibitors of oxidosqualene cyclases from Saccharomyces cerevisiae, Trypanosoma cruzi, and Pneumocystis carinii. Lipids 39(10):1007-12
Milla P, et al.  (2002) Yeast oxidosqualene cyclase (Erg7p) is a major component of lipid particles. J Biol Chem 277(4):2406-12
Segura MJ, et al.  (2002) Directed evolution experiments reveal mutations at cycloartenol synthase residue His477 that dramatically alter catalysis. Org Lett 4(25):4459-62
Milla P, et al.  (1999) 19-Azasqualene-2,3-epoxide and its N-oxide: metabolic fate and inhibitory effect on sterol biosynthesis in Saccharomyces cerevisiae. Lipids 34(7):681-8
Venkatramesh M, et al.  (1996) Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:delta 24(25)-sterol methyl transferase from Saccharomyces cerevisiae. Biochim Biophys Acta 1299(3):313-24
Balliano G, et al.  (1992) Characterization and partial purification of squalene-2,3-oxide cyclase from Saccharomyces cerevisiae. Arch Biochem Biophys 293(1):122-9
Ceruti M, et al.  (1992) 2,3-Epoxy-10-aza-10,11-dihydrosqualene, a high-energy intermediate analogue inhibitor of 2,3-oxidosqualene cyclase. J Med Chem 35(16):3050-8
Nes WR and Dhanuka IC  (1988) Inhibition of sterol synthesis by delta 5-sterols in a sterol auxotroph of yeast defective in oxidosqualene cyclase and cytochrome P-450. J Biol Chem 263(24):11844-50