PRP8/YHR165C Literature Guide Help

Other names published for PRP8: DBF3, DNA39, RNA8, SLT21, USA2, YHR165C

PRP8 - Strains/Constructs (53)

ReferenceOther Genes Addressed
Query CC and Konarska MM  (2012) CEF1/CDC5 alleles modulate transitions between catalytic conformations of the spliceosome. RNA 18(5):1001-13
Grainger RJ, et al.  (2009) Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome. RNA 15(12):2161-73
Maeder C, et al.  (2009) ATP-dependent unwinding of U4/U6 snRNAs by the Brr2 helicase requires the C terminus of Prp8. Nat Struct Mol Biol 16(1):42-8
Pandit S, et al.  (2009) Spp382p interacts with multiple yeast splicing factors, including possible regulators of Prp43 DExD/H-Box protein function. Genetics 183(1):195-206
Zhang L, et al.  (2009) Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2. Nat Struct Mol Biol 16(7):731-9
Bellare P, et al.  (2008) A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol 15(5):444-51
Hacker I, et al.  (2008) Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy. Nat Struct Mol Biol 15(11):1206-12
Ritchie DB, et al.  (2008) Structural elucidation of a PRP8 core domain from the heart of the spliceosome. Nat Struct Mol Biol 15(11):1199-205
Wilmes GM, et al.  (2008) A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol Cell 32(5):735-46
Aronova A, et al.  (2007) Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing. RNA 13(9):1437-44
Boon KL, et al.  (2007) prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeast. Nat Struct Mol Biol 14(11):1077-83
Kaplan Y and Kupiec M  (2007) A role for the yeast cell cycle/splicing factor Cdc40 in the G(1)/S transition. Curr Genet 51(2):123-40
Liu L, et al.  (2007) Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing. Nat Struct Mol Biol 14(6):519-26
Pleiss JA, et al.  (2007) Rapid, transcript-specific changes in splicing in response to environmental stress. Mol Cell 27(6):928-37
Bellare P, et al.  (2006) Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA 12(2):292-302
Boon KL, et al.  (2006) Prp8p dissection reveals domain structure and protein interaction sites. RNA 12(2):198-205
Konarska MM, et al.  (2006) Repositioning of the reaction intermediate within the catalytic center of the spliceosome. Mol Cell 21(4):543-53
Tardiff DF and Rosbash M  (2006) Arrested yeast splicing complexes indicate stepwise snRNP recruitment during in vivo spliceosome assembly. RNA 12(6):968-79
Turner IA, et al.  (2006) Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome. RNA 12(3):375-86
Brenner TJ and Guthrie C  (2005) Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activation. Genetics 170(3):1063-80
Gornemann J, et al.  (2005) Cotranscriptional spliceosome assembly occurs in a stepwise fashion and requires the cap binding complex. Mol Cell 19(1):53-63
Lacadie SA and Rosbash M  (2005) Cotranscriptional spliceosome assembly dynamics and the role of U1 snRNA:5'ss base pairing in yeast. Mol Cell 19(1):65-75
Query CC and Konarska MM  (2004) Suppression of multiple substrate mutations by spliceosomal prp8 alleles suggests functional correlations with ribosomal ambiguity mutants. Mol Cell 14(3):343-54
Chawla G, et al.  (2003) Dependence of pre-mRNA introns on PRP17, a non-essential splicing factor: implications for efficient progression through cell cycle transitions. Nucleic Acids Res 31(9):2333-43
van Nues RW and Beggs JD  (2001) Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae. Genetics 157(4):1451-67
Ben-Yehuda S, et al.  (2000) Extensive genetic interactions between PRP8 and PRP17/CDC40, two yeast genes involved in pre-mRNA splicing and cell cycle progression. Genetics 154(1):61-71
Ben-Yehuda S, et al.  (2000) Genetic and physical interactions between factors involved in both cell cycle progression and pre-mRNA splicing in Saccharomyces cerevisiae. Genetics 156(4):1503-17
Kuhn AN and Brow DA  (2000) Suppressors of a cold-sensitive mutation in yeast U4 RNA define five domains in the splicing factor Prp8 that influence spliceosome activation. Genetics 155(4):1667-82
Collins CA and Guthrie C  (1999) Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. Genes Dev 13(15):1970-82
Kuhn AN, et al.  (1999) Splicing factor Prp8 governs U4/U6 RNA unwinding during activation of the spliceosome. Mol Cell 3(1):65-75