FCY1/YPR062W Literature Guide Help

Other names published for FCY1: yCD, cytosine deaminase, YPR062W

FCY1 - Strains/Constructs (22)

ReferenceOther Genes Addressed
Quinto-Alemany D, et al.  (2012) Yeasts acquire resistance secondary to antifungal drug treatment by adaptive mutagenesis. PLoS One 7(7):e42279
Wang J, et al.  (2012) Role of glutamate 64 in the activation of the prodrug 5-fluorocytosine by yeast Cytosine deaminase. Biochemistry 51(1):475-86
Johnson AJ, et al.  (2011) Comparative analysis of enzyme and pathway engineering strategies for 5FC-mediated suicide gene therapy applications. Cancer Gene Ther 18(8):533-42
Ear PH and Michnick SW  (2009) A general life-death selection strategy for dissecting protein functions. Nat Methods 6(11):813-6
Foloppe J, et al.  (2008) Targeted delivery of a suicide gene to human colorectal tumors by a conditionally replicating vaccinia virus. Gene Ther 15(20):1361-71
Paluszynski JP, et al.  (2008) Genetic prerequisites for additive or synergistic actions of 5-fluorocytosine and fluconazole in baker's yeast. Microbiology 154(Pt 10):3154-64
Stolworthy TS, et al.  (2008) Yeast cytosine deaminase mutants with increased thermostability impart sensitivity to 5-fluorocytosine. J Mol Biol 377(3):854-69
Zamboni S, et al.  (2008) Genetic construction, expression, and characterization of a single chain anti-CEA antibody fused to cytosine deaminase from yeast. Int J Oncol 32(6):1245-51
Fogar P, et al.  (2007) Suicide gene therapy with the yeast fusion gene cytosine deaminase/uracil phosphoribosyltransferase is not enough for pancreatic cancer. Pancreas 35(3):224-31
Simpson GR, et al.  (2006) Combination of a fusogenic glycoprotein, prodrug activation, and oncolytic herpes simplex virus for enhanced local tumor control. Cancer Res 66(9):4835-42
Graepler F, et al.  (2005) Bifunctional chimeric SuperCD suicide gene -YCD: YUPRT fusion is highly effective in a rat hepatoma model. World J Gastroenterol 11(44):6910-9
Hartzog PE, et al.  (2005) Cytosine deaminase MX cassettes as positive/negative selectable markers in Saccharomyces cerevisiae. Yeast 22(10):789-98
Korkegian A, et al.  (2005) Computational thermostabilization of an enzyme. Science 308(5723):857-60
Xiong MP and Kwon GS  (2005) PEGylation of yeast cytosine deaminase for pretargeting. J Pharm Sci 94(6):1249-58
Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
Ireton GC, et al.  (2003) The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy. Structure 11(8):961-72
Kurtz JE, et al.  (2002) The URH1 uridine ribohydrolase of Saccharomyces cerevisiae. Curr Genet 41(3):132-41
Erbs P, et al.  (2000) In vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase/uracil phosphoribosyltransferase fusion gene. Cancer Res 60(14):3813-22
Kievit E, et al.  (2000) Yeast cytosine deaminase improves radiosensitization and bystander effect by 5-fluorocytosine of human colorectal cancer xenografts. Cancer Res 60(23):6649-55
Hamstra DA, et al.  (1999) Enzyme/prodrug therapy for head and neck cancer using a catalytically superior cytosine deaminase. Hum Gene Ther 10(12):1993-2003
Kurtz JE, et al.  (1999) New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Curr Genet 36(3):130-6
Erbs P, et al.  (1997) Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans. Curr Genet 31(1):1-6